Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Division of Hematology, Saitama Medical Center, Jichi Medical University, Omiya, Saitama, Japan.
Int J Cancer. 2018 Mar 15;142(6):1130-1138. doi: 10.1002/ijc.31135. Epub 2017 Nov 21.
Although coffee and green tea are suggested to reduce the risk of some types of cancers, only a few epidemiological studies have investigated their effect on the risk of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Here, we investigated the association of coffee and green tea consumption and the risk of AML and MDS in a large-scale population-based cohort study in Japan. A total of 95,807 Japanese subjects (45,937 men and 49,870 women; age 40-69 years at baseline) were followed to the end of 2012, for an average of 18 years. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between coffee and green tea consumption at baseline and the risk of AML and MDS were assessed using a Cox proportional hazards model with adjustment for potential confounders. During 1,751.956 person-years, we identified 85 AML cases and 70 MDS cases. Our findings showed no significant association between coffee consumption and the risk of AML, or between green tea consumption and the risk of AML or MDS. In contrast, we observed a decreasing dose-response relationship between coffee consumption and the risk of MDS among men (almost none: reference, 1-4 times/week: HR = 0.83, 95% CI: 0.43-1.62; ≥1cups/day: HR = 0.47, 0.22-0.99, p for trend = 0.049). Stratified analysis by smoking status suggested that the observed relative risk for AML and MDS of coffee drinkers relative to non-coffee drinkers might be due to residual confounding by smoking. These findings deserve further investigation in future studies.
尽管有研究表明咖啡和绿茶可以降低某些类型癌症的风险，但仅有少数流行病学研究调查了它们对急性髓系白血病（AML）和骨髓增生异常综合征（MDS）风险的影响。在这里，我们在日本一项大规模基于人群的队列研究中调查了咖啡和绿茶消费与 AML 和 MDS 风险之间的关联。共有 95807 名日本受试者（45937 名男性和 49870 名女性；基线时年龄为 40-69 岁）随访至 2012 年底，平均随访时间为 18 年。使用 Cox 比例风险模型，根据潜在混杂因素进行调整，评估基线时咖啡和绿茶消费与 AML 和 MDS 风险之间的关联的风险比（HR）和 95%置信区间（95%CI）。在 1751.956 人年期间，我们共确定了 85 例 AML 病例和 70 例 MDS 病例。我们的研究结果表明，咖啡消费与 AML 风险之间没有显著关联，绿茶消费与 AML 或 MDS 风险之间也没有显著关联。相比之下，我们观察到男性中咖啡消费与 MDS 风险之间存在剂量反应关系（几乎没有：参考，1-4 次/周：HR=0.83，95%CI：0.43-1.62；≥1 杯/天：HR=0.47，0.22-0.99，p 趋势=0.049）。按吸烟状况进行的分层分析表明，与非咖啡饮用者相比，咖啡饮用者 AML 和 MDS 的相对风险可能归因于吸烟的残余混杂。这些发现值得在未来的研究中进一步探讨。
