18F-FSPG PET/CT 检测到的心内转移。
Intracardiac Metastases Detected by 18F-FSPG PET/CT.
出版信息
Clin Nucl Med. 2018 Jan;43(1):28-30. doi: 10.1097/RLU.0000000000001883.
Abstract
PET/CT imaging is frequently used for cancer diagnosis and restaging as metabolically active cells, including cancer, utilize glucose for proliferation. F-FDG is the most commonly utilized radiopharmaceutical in PET/CT imaging. Limitations of F-FDG imaging include intense physiologic uptake in benign tissues such as the brain and myocardium. We present a case of non-small cell lung cancer with myocardial and pericardial metastases obscured by physiologic F-FDG cardiac uptake but detected with the investigational PET radiotracer (4S)-4-(3-F-fluoropropyl)-L-glutamate (F-FSPG), which targets a pathway associated with glutathione biosynthesis. This case demonstrates the added value of F-FSPG PET/CT imaging.
摘要
PET/CT 成像常用于癌症诊断和分期，因为代谢活跃的细胞，包括癌症，会利用葡萄糖进行增殖。F-FDG 是 PET/CT 成像中最常用的放射性药物。F-FDG 成像的局限性包括在良性组织（如大脑和心肌）中摄取量较高。我们报告了一例非小细胞肺癌患者，其心肌和心包转移灶被生理性 F-FDG 心脏摄取所掩盖，但通过研究性 PET 放射性示踪剂（4S）-4-（3-F-氟丙基）-L-谷氨酸（F-FSPG）检测到，该示踪剂靶向与谷胱甘肽生物合成相关的途径。该病例表明了 F-FSPG PET/CT 成像的附加价值。
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