Sun S-Y, Zhao B-Q, Wang J, Mo Z-X, Zhao Y-N, Wang Y, He J
School of Medicine, Shandong University, Jinan.
Departments of Pathology and Gastroenterology, People's Hospital of Rizhao.
Dis Esophagus. 2018 Feb 1;31(2). doi: 10.1093/dote/dox125.
As a hallmark of platelet activation, mean platelet volume (MPV) has been identified to be associated with various malignancies. However, the correlation between MPV, mean platelet volume/platelet count ratio (MPR), and esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of this study is to clarify the relevance of MPV and MPR in patients with locally advanced ESCC. Four hundred and fifty-seven cases with newly diagnosed locally advanced ESCC followed by radical surgery and 240 healthy subjects matched for age and gender were included in this study. We retrospectively compared various hematological variables between groups and analyzed the correlation between MPV, MPR, and patients' clinicopathologic characteristics. Preoperative MPV and MPR were found to be significantly decreased in locally advanced ESCC when compared to healthy controls, they were (8.14 ± 1.09 fL vs. 10.23 ± 0.78 fL, P < 0.0001) and (0.03875 ± 0.02645 vs. 0.04463 ± 0.00972, P = 0.001), respectively. In addition, patients with advanced tumor length (≥4 cm) tended to have lower MPV levels (8.03 ± 1.11 fL versus 8.33 ± 1.21 fL, P = 0.005), while there was no difference between other subgroups. Moreover, decreased MPR was significantly correlated with advanced tumor length (P < 0.001) when divided at a median of 0.03420. Decreased MPV and MPR were significantly associated with locally advanced ESCC. Thus, they might be helpful in screening and risk stratification for locally advanced ESCC in combination with other approaches.
作为血小板活化的一个标志，平均血小板体积（MPV）已被确定与多种恶性肿瘤相关。然而，MPV、平均血小板体积/血小板计数比值（MPR）与食管鳞状细胞癌（ESCC）之间的相关性仍不清楚。本研究的目的是阐明MPV和MPR在局部晚期ESCC患者中的相关性。本研究纳入了457例新诊断的局部晚期ESCC患者，这些患者均接受了根治性手术，以及240例年龄和性别匹配的健康受试者。我们回顾性比较了两组之间的各种血液学变量，并分析了MPV、MPR与患者临床病理特征之间的相关性。与健康对照组相比，发现局部晚期ESCC患者术前的MPV和MPR显著降低，分别为（8.14±1.09 fL对10.23±0.78 fL，P<0.0001）和（0.03875±0.02645对0.04463±0.00972，P = 0.001）。此外，肿瘤长度≥4 cm的晚期患者往往具有较低的MPV水平（8.03±1.11 fL对8.33±1.21 fL，P = 0.005），而其他亚组之间没有差异。此外，当以中位数0.03420划分时，MPR降低与肿瘤长度增加显著相关（P<0.001）。MPV和MPR降低与局部晚期ESCC显著相关。因此，它们可能有助于结合其他方法对局部晚期ESCC进行筛查和风险分层。
