Mosala Nezhad Zahra, Poncelet Alain, Fervaille Caroline, Gianello Pierre
Department of Cardiovascular and Thoracic Surgery, Cliniques Universitaire Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium.
Thorac Cardiovasc Surg. 2019 Jan;67(1):44-49. doi: 10.1055/s-0037-1607332. Epub 2017 Oct 27.
Comparing the structural changes, and local host reactions to CorMatrix (CorMatrix Cardiovascular Inc., Roswell, Georgia, United States) and different biomaterials implanted subcutaneously in growing pig model.
Four pigs harboring implanted patches of CorMatrix, Vascutek porcine pericardium (Vascutek; Scotland, United Kingdom), SJM bovine pericardium (St. Jude Medical, Inc., Minnesota, United States), and Gore-Tex (W. L. Gore & Associates GmbH, Flagstaff, Arizona, United States) were studied for 1, 3, 6, and 12 months. The explants were examined histologically.
CorMatrix showed gradual and consistent patch resorption and subsiding inflammatory and fibrosis process. Full scaffold degradation and replacement by mild fibrosis and subcutaneous tissue were seen by 1 year. Xenopericardial patches remained intact, and the initially severe inflammatory and fibrotic reactions reduced gradually to moderate fibrosis and chronic inflammation. Gore-Tex showed foreign body reaction.
Patches were biotolerated by pigs. Xenopericardial patches elicited encapsulating fibrosis and no remodeling. CorMatrix resorbs completely and degrades consistently without leaving residues. Lack of encapsulating fibrosis toward CorMatrix allows tissue ingrowth and matrix remodeling.
在生长猪模型中，比较CorMatrix（美国佐治亚州罗斯韦尔市CorMatrix心血管公司）与皮下植入的不同生物材料的结构变化及局部宿主反应。
对4只植入CorMatrix、Vascutek猪心包（Vascutek；英国苏格兰）、圣犹达医疗公司（美国明尼苏达州）的SJM牛心包以及戈尔特斯（美国亚利桑那州弗拉格斯塔夫市W. L. 戈尔联合公司）补片的猪进行1、3、6和12个月的研究。对取出的植入物进行组织学检查。
CorMatrix显示出补片逐渐且持续的吸收以及炎症和纤维化过程的消退。到1年时可见完全的支架降解并被轻度纤维化和皮下组织替代。异种心包补片保持完整，最初严重的炎症和纤维化反应逐渐减轻为中度纤维化和慢性炎症。戈尔特斯显示出异物反应。
补片在猪体内具有生物耐受性。异种心包补片引发包裹性纤维化且无重塑。CorMatrix完全吸收且持续降解，不留残余物。对CorMatrix缺乏包裹性纤维化允许组织长入和基质重塑。
