Serin Gediz, Baylancicek Serdar, Aksoy Elif, Polat Senol, Sağlican Yeşim, Inanli Selcuk
Department of Otorhinolaryngology, Acibadem University School of Medicine, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
J Craniofac Surg. 2013 Jul;24(4):1428-30. doi: 10.1097/SCS.0b013e31828dcc06.
OBJECTIVE/HYPOTHESIS: The aim of this study was to assess the tissue response to Gore-Tex (expanded polytetrafluoroethylene) in rats and compare the results of surgical placement modalities.
Prospective animal study.
Experiments were performed in 18 young Sprague-Dawley rats that were divided into 3 groups. Gore-Tex patches were implanted subcutaneously over the periosteum in the first group and under the periosteum in the other groups. Gore-Tex was immersed in an antibiotic-containing solution in the third group. All animals were killed 4 weeks after the procedure. The tissue samples were stained with hematoxylin and eosin stain and evaluated using a light microscope.
The Gore-Tex patches were displaced and not observed at the originally implanted sites in the first group. The Gore-Tex patches were observed at the originally implanted sites in the other groups. In group 1, edema and inflammation were prominent. In the second group, ossification was detected in 5 rats and foreign-body reaction and edema were identified in 1 rat. In the third group, all of the rats were found to have developed ossification, but no inflammatory reactions were observed.
The results suggest that implanting synthetic graft materials immersed in an antibiotic solution at the subperiosteal plane provides better stabilization and low complication rates.
目的/假设：本研究的目的是评估大鼠对戈尔特斯（膨体聚四氟乙烯）的组织反应，并比较手术植入方式的结果。
前瞻性动物研究。
对18只年轻的斯普拉格-道利大鼠进行实验，将其分为3组。第一组将戈尔特斯补片皮下植入骨膜上方，其他组将其植入骨膜下方。第三组将戈尔特斯浸泡在含抗生素的溶液中。所有动物在手术后4周处死。组织样本用苏木精和伊红染色，并使用光学显微镜进行评估。
第一组中戈尔特斯补片发生移位，在最初植入部位未观察到。其他组在最初植入部位观察到戈尔特斯补片。在第一组中，水肿和炎症明显。在第二组中，5只大鼠检测到骨化，1只大鼠发现异物反应和水肿。在第三组中，所有大鼠均出现骨化，但未观察到炎症反应。
结果表明，在骨膜下平面植入浸泡在抗生素溶液中的合成移植物材料可提供更好的稳定性和低并发症发生率。
