Wang Ya-Di, Zhang Yang, Sun Bo, Leng Xiao-Wei, Li Ya-Juan, Ren Li-Qun
a Department of Pharmacology and Toxicology, School of Pharmacy , Jilin University , Changchun 130021 , China.
b Department of Oncology , The Third Affiliated Hospital, Jinzhou Medical University , Jinzhou 121012 , China.
J Asian Nat Prod Res. 2018 Apr;20(4):361-373. doi: 10.1080/10286020.2017.1394292. Epub 2017 Oct 27.
We established both an acute and chronic cardiac toxicity rat model, which showed pretreatment with rutin attenuated pirarubicin-induced myocardial histopathological injury, electrocardiogram abnormalities, and cardiac dysfunction. Rutin also significantly reduced serum levels of MDA, BNP, CK-MB, CTnT, and LDH and increased serum SOD levels. Treatment with rutin and dexrazoxane resulted in an increase in Bcl-2/Bax ratio (p < 0.05) and reduction in JNK and Caspase-3 protein levels, compared to the pirarubicin group (all p < 0.05). Furthermore, rutin at a dose of 50 mg/kg significantly attenuated the above-mentioned alterations. Our study suggests the antioxidant and anti-apoptotic properties of rutin may be responsible for the cardioprotective effects observed.
我们建立了急性和慢性心脏毒性大鼠模型，结果显示，芦丁预处理可减轻吡柔比星诱导的心肌组织病理学损伤、心电图异常和心脏功能障碍。芦丁还显著降低了血清丙二醛（MDA）、脑钠肽（BNP）、肌酸激酶同工酶（CK-MB）、心肌肌钙蛋白T（CTnT）和乳酸脱氢酶（LDH）水平，并提高了血清超氧化物歧化酶（SOD）水平。与吡柔比星组相比，芦丁和右丙亚胺治疗导致Bcl-2/Bax比值增加（p<0.05），JNK和半胱天冬酶-3（Caspase-3）蛋白水平降低（均为p<0.05）。此外，50mg/kg剂量的芦丁显著减轻了上述改变。我们的研究表明，芦丁的抗氧化和抗凋亡特性可能是观察到的心脏保护作用的原因。
