Capittini Cristina, Messina Francesco, Puglisi Fabrizio, Azzaro Maria, Toscano Sebastiana, De Silvestri Annalisa, Tinelli Carmine, Sortino Grazia
Biometry and Clinical Epidemiology, Scientific Direction, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
Hum Immunol. 2018 Jan;79(1):5-12. doi: 10.1016/j.humimm.2017.10.008. Epub 2017 Oct 25.
A geographical stratification of Killer Immunoglobulin-like Receptors (KIR) has been reported worldwide. We first analyzed the distribution of 15 KIR genes in a sample of 50 East-Sicilians (ES). We used a Principal Component Analysis (PCA) to compare the KIR genetic content among ES and 10 modern populations who are descendants of the ancient invaders of Sicily: Spanish, French, Norwegians, Swedes, Finns, Tunisians, Moroccans, Arabs, Greeks, Turks. We also included a sample of Sardinians, and Senegalese (as outlier group). Then, we also compared the HLA-A, HLA-B and HLA-C allelic frequencies among ES and the same populations investigated for KIR. As to HLA-A and HLA-B polymorphisms, ES are close to Greek population who invaded the island for long time until 827 CE; while HLA-C and KIR distribution in ES are close to Spanish population that invaded Sicily (and Sardinia) starting from 1283. As to KIR, ES are close to Spanish and Sardinians. The immunogenetic fingerprint of ES may be the finely balanced result of the invasions that overwhelmed Sicily over the centuries.
全球范围内已有关于杀伤细胞免疫球蛋白样受体（KIR）的地理分层报道。我们首先分析了50名西西里岛东部居民（ES）样本中15个KIR基因的分布情况。我们使用主成分分析（PCA）来比较ES与10个现代人群的KIR基因组成，这10个现代人群是西西里岛古代入侵者的后裔：西班牙人、法国人、挪威人、瑞典人、芬兰人、突尼斯人、摩洛哥人、阿拉伯人、希腊人、土耳其人。我们还纳入了撒丁岛人和塞内加尔人样本（作为异常值组）。然后，我们还比较了ES与上述针对KIR进行研究的相同人群之间的HLA - A、HLA - B和HLA - C等位基因频率。关于HLA - A和HLA - B多态性，ES与公元827年之前长期入侵该岛的希腊人群相近；而ES中HLA - C和KIR的分布与1283年起入侵西西里岛（和撒丁岛）的西班牙人群相近。至于KIR，ES与西班牙人和撒丁岛人相近。ES的免疫遗传指纹可能是几个世纪以来席卷西西里岛的多次入侵所形成的精细平衡的结果。
