Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 Rue Sicotte, Saint-Hyacinthe, Québec, J2S 2M2, Canada.
Microb Pathog. 2017 Dec;113:129-134. doi: 10.1016/j.micpath.2017.10.037. Epub 2017 Nov 5.
Enterotoxigenic Escherichia coli are responsible for causing secretory diarrhea in animal(s), including human(s). This group of microorganisms is classified on the basis of production of toxins acting on the intestinal epithelium of the small intestine. Various enterotoxins, heat-labile and heat-resistant, are produced by distinct strains of ETEC. Although the mechanisms of action of ETEC enterotoxins were shown to involve diverse ion channels recent data suggest that these molecules could also be involved in disruption of the permeability barrier of the intestinal epithelium. More precisely, the tight junctions directly responsible for the selective permeability of the intestinal tissue could be affected. Studies indicating a change in TJ following exposure of cell monolayers or animal models either to pure enterotoxins or to ETEC strains producing one or more of these toxic molecules will be discussed.
肠产毒性大肠杆菌是引起动物（包括人类）分泌性腹泻的原因。这群微生物是根据其在小肠肠上皮细胞产生毒素的能力来分类的。不同的肠毒素，包括不耐热和耐热毒素，是由不同的 ETEC 菌株产生的。尽管 ETEC 肠毒素的作用机制涉及多种离子通道，但最近的数据表明，这些分子也可能参与破坏肠上皮细胞的通透性屏障。更确切地说，直接负责肠道组织选择性通透性的紧密连接可能会受到影响。本文将讨论表明在细胞单层或动物模型中暴露于纯肠毒素或产生一种或多种这些毒性分子的 ETEC 菌株后，TJ 发生变化的研究。
