Oral & Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Social Determinants of Health Research Center, Mashhad University o Medical Sciences, Mashhad, Iran.
Photodiagnosis Photodyn Ther. 2018 Mar;21:19-27. doi: 10.1016/j.pdpdt.2017.10.019. Epub 2017 Oct 24.
The present study aimed to determine the diagnostic value of a native fluorescence visualization device in the identification of oral malignant/dysplastic lesions.
This study involved 45 patients who had oral lesions that were suspected to be malignant, potentially malignant, or benign. The patients visited the Oral Medicine Department of the Mashhad Dental School. The sensitivity, specificity, positive and negative predictive values, and likelihood ratio of this device were determined.
The histopathological assessment of samples showed 9 cases of oral squamous cell carcinoma and 12 lesions with dysplasia. Ten samples of dysplastic lesions and all malignant lesions appeared dark or red/orange when examined with the native fluorescence visualization device. In 90% of the dysplastic/malignant lesions, the label-free fluorescence results were positive. The sensitivity, specificity, and positive and negative predictive values of this device were 90%, 15%, 40%, and 71%, respectively.
The native fluorescence visualization device can be used in specialized centers as an adjunctive device to increase the sensitivity of a clinical examination, but is not capable of distinguishing benign lesions from malignant and dysplastic ones due to its low specificity.
本研究旨在确定一种自发荧光可视化设备在识别口腔恶性/异型病变中的诊断价值。
本研究纳入了 45 名口腔病变疑似恶性、潜在恶性或良性的患者。这些患者均来自马什哈德牙科学校口腔医学系。本研究确定了该设备的敏感性、特异性、阳性和阴性预测值以及似然比。
组织病理学评估显示，9 例为口腔鳞状细胞癌，12 例为异型增生病变。自发荧光可视化设备检查时，10 例异型增生病变和所有恶性病变均呈现暗或红/橙色。在 90%的异型增生/恶性病变中，无标记荧光结果为阳性。该设备的敏感性、特异性、阳性预测值和阴性预测值分别为 90%、15%、40%和 71%。
自发荧光可视化设备可在专业中心作为辅助设备使用，以提高临床检查的敏感性，但由于特异性低，无法区分良性病变与恶性和异型病变。
