Department of Endocrinology, Diabetology, and Isotope Therapy, Medical University of Wroclaw, 50-367 Wrocław, Poland.
Endokrynol Pol. 2012;63(6):447-55.
In the 1980s, the idea evolved that some individuals with normal weight (Metabolically Obese, Normal-Weight), who probably have increased abdominal fat, have metabolic disturbances related to obesity. This observation initiated the concept of the metabolically obese but normal-weight syndrome (MONW). Since then, there have been only a few studies in non-obese subjects. MONW men and women should be regarded as at high risk for cardiovascular disease.
A group of 854 randomly chosen non-obese men and women, 20-40 years of age, was selected from three different areas of Poland - Szczecin, Krakow and Wroclaw. All subjects were interviewed and underwent physical examination, anthropometric measurements (waist circumference, hip circumference, BMI and WHR) as well as densitometry (total body DPX, total fat, android/gynoid deposit). Serum level of fasting glucose and insulin, indices of insulin sensibility (QUICKI) and insulin resistance (HOMA, FIRI), total cholesterol, triglycerides and HDL-C were measured using commercially available kits. LDL-C level was calculated using Friedewald's formula.
The total amassed fatty tissue and its android deposit was found to be significantly greater in MONW men and women. MONW women were found to exhibit increased levels of triglycerides and LDL-C but lower levels of HDL-C. In women with excess abdominal fat (EAF), fasting glucose and insulin levels, HOMA and FIRI were considerably higher, while QUICKI was lower. Triglyceride and LDL-C levels were also higher while HDL-C levels were lower. In men with EAF, increased levels of total cholesterol and LDL-C were confirmed.
The occurrence of MONW is contingent upon the diagnosis criterion and increases when the criterion represents the value of HOMA - 21.76% in women and 31.42% in men. The frequency of MONW occurrence is lower when the criterion for abdominal fat content limit is used, amounting to 15.78% in women and 7.83% in men.
20 世纪 80 年代，人们逐渐认识到一些体重正常（代谢肥胖，正常体重）的个体，他们可能腹部脂肪增加，存在与肥胖相关的代谢紊乱。这一观察结果引发了代谢肥胖但体重正常综合征（MONW）的概念。此后，仅有少数非肥胖受试者的研究。MONW 男性和女性应被视为心血管疾病的高危人群。
从波兰的三个不同地区——什切青、克拉科夫和弗罗茨瓦夫，随机选择了 854 名年龄在 20-40 岁的非肥胖男性和女性。所有受试者均接受了访谈和体检，包括人体测量学测量（腰围、臀围、BMI 和 WHR）以及密度测量（全身 DPX、总脂肪、安卓/女性脂肪沉积）。使用商业试剂盒测量空腹血糖和胰岛素、胰岛素敏感性指数（QUICKI）和胰岛素抵抗指数（HOMA、FIRI）、总胆固醇、甘油三酯和高密度脂蛋白胆固醇。使用 Friedewald 公式计算 LDL-C 水平。
MONW 男性和女性的总脂肪组织及其安卓沉积明显更大。MONW 女性的甘油三酯和 LDL-C 水平升高，而 HDL-C 水平降低。腹部脂肪过多（EAF）的女性，空腹血糖和胰岛素水平、HOMA 和 FIRI 明显较高，而 QUICKI 较低。甘油三酯和 LDL-C 水平也较高，而 HDL-C 水平较低。腹部脂肪过多的男性，总胆固醇和 LDL-C 水平升高。
MONW 的发生取决于诊断标准，当标准代表 HOMA 值时会增加——女性为 21.76%，男性为 31.42%。当使用腹部脂肪含量极限的标准时，MONW 的发生频率较低，女性为 15.78%，男性为 7.83%。
