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非规范的GA和GG 5'内含子供体剪接位点在桡足类动物中很常见。

Noncanonical GA and GG 5' Intron Donor Splice Sites Are Common in the Copepod .

作者信息

Robertson Hugh M

机构信息

Department of Entomology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801

出版信息

G3 (Bethesda). 2017 Dec 4;7(12):3967-3969. doi: 10.1534/g3.117.300189.

DOI:10.1534/g3.117.300189
PMID:29079681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5714493/
Abstract

The noncanonical 5' intron donor splice sites GA and GG are exceedingly rare in described eukaryotic genomes; however, they are present in ∼12% of introns in the genome of the copepod Failure to recognize the high frequency of these donor sites compromised the modeling of genes in this newly sequenced genome, including 10 conserved ionotropic glutamate receptor (GluR) family genes curated herein. These introns appear to have been acquired recently, along with many additional idiosyncratic introns. Their high frequency implies the evolution of modified intron donor splice site recognition in this copepod.

摘要

非经典的5'内含子供体剪接位点GA和GG在已描述的真核生物基因组中极其罕见；然而，它们存在于桡足类基因组约12%的内含子中。未能识别这些供体位点的高频率情况影响了对这个新测序基因组中基因的建模，包括本文整理的10个保守的离子型谷氨酸受体（GluR）家族基因。这些内含子似乎是最近获得的，还有许多其他特殊的内含子。它们的高频率意味着这种桡足类动物中内含子供体剪接位点识别机制的进化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5f7/5714493/628a97f55405/3967f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5f7/5714493/628a97f55405/3967f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5f7/5714493/628a97f55405/3967f1.jpg

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