使用 iPSC 衍生的神经细胞进行神经疾病建模：神经疾病的 iPSC 建模。
Modeling neurological diseases using iPSC-derived neural cells : iPSC modeling of neurological diseases.
机构信息
Division of Stem Cell Biology, Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, Duarte, CA, 91010, USA.
出版信息
Cell Tissue Res. 2018 Jan;371(1):143-151. doi: 10.1007/s00441-017-2713-x. Epub 2017 Oct 28.
Abstract
Developing efficient models for neurological diseases enables us to uncover disease mechanisms and develop therapeutic strategies to treat them. Discovery of reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has revolutionized the way of modeling human diseases, especially neurological diseases. Currently almost all types of neural cells, including but not limited to neural stem cells, neurons, astrocytes, oligodendrocytes and microglia, can be derived from iPSCs following developmental principles. These iPSC-derived neural cells provide valuable tools for studying neurological disease mechanisms, developing potential therapies, and deepening our understanding of the nervous system.
摘要
开发用于神经疾病的高效模型使我们能够揭示疾病机制并开发治疗这些疾病的治疗策略。将体细胞重编程为诱导多能干细胞（iPSC）的发现彻底改变了人类疾病建模的方式，尤其是神经疾病。目前，几乎所有类型的神经细胞，包括但不限于神经干细胞、神经元、星形胶质细胞、少突胶质细胞和小胶质细胞，都可以按照发育原理从 iPSC 中衍生出来。这些 iPSC 衍生的神经细胞为研究神经疾病机制、开发潜在治疗方法以及加深我们对神经系统的理解提供了有价值的工具。
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