Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou Dadao Bei Street 1838#, Guangzhou, 510515, Guangdong, China.
Laboratory for Precision Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
J Neurooncol. 2018 Jan;136(1):41-50. doi: 10.1007/s11060-017-2637-z. Epub 2017 Oct 27.
Cytochrome c oxidase subunit 7A2 (COX7A2) is a nuclear-encoded polypeptide involved in assembly and regulation of cytochrome c oxidase (COX). Changes in the respiratory chain as big complex are known to be associated with cancer, but little research has been performed to discover COX7A2 as a prognostic marker in glioma. In the present study, we investigated COX7A2 expression and its prognostic significance in glioma. Glioma surgical tissue samples were taken from 126 patients who had been followed up from 4 to 51 months. Immunohistochemistry were used to test COX7A2 expression in the 126 tumor samples. Eighty-six of 126 (68.3%) paraffin-embedded glioma biopsies showed high expression of COX7A2. Statistical analysis displayed that there was significant difference of COX7A2 expression level in patients categorized according to WHO classification. Kaplan-Meier survival analysis revealed that patients with higher COX7A2 expression had longer overall survival time and better prognosis. R2: microarray analysis based on Tumor Glioma French 284 database, Tumor Glioblastoma TCGA 540 database, and Tumor Glioma Kawaguchi 50 database testified that high expression of COX7A2 is associated with a good prognosis in patients with glioma. Multivariate analysis showed that COX7A2 high expression was an independent prognostic indicator for survival. Our results suggest that COX7A2 could be served as a valuable prognostic marker of glioma.
细胞色素 c 氧化酶亚基 7A2（COX7A2）是一种参与细胞色素 c 氧化酶（COX）组装和调节的核编码多肽。已知呼吸链作为大复合物的变化与癌症有关，但很少有研究发现 COX7A2 是神经胶质瘤的预后标志物。在本研究中，我们研究了 COX7A2 在神经胶质瘤中的表达及其预后意义。从 126 名随访 4 至 51 个月的患者中获取神经胶质瘤手术组织样本。使用免疫组织化学方法检测 126 个肿瘤样本中的 COX7A2 表达。在 126 例石蜡包埋的神经胶质瘤活检中，有 86 例（68.3%）显示 COX7A2 高表达。统计分析显示，根据世界卫生组织（WHO）分类，COX7A2 表达水平在患者之间存在显著差异。Kaplan-Meier 生存分析显示，COX7A2 表达较高的患者总生存时间更长，预后更好。R2：基于 Tumor Glioma French 284 数据库、Tumor Glioblastoma TCGA 540 数据库和 Tumor Glioma Kawaguchi 50 数据库的微阵列分析表明，COX7A2 高表达与神经胶质瘤患者的良好预后相关。多变量分析显示 COX7A2 高表达是生存的独立预后指标。我们的结果表明，COX7A2 可能是神经胶质瘤有价值的预后标志物。
