Department of Biochemistry, Centre for Biological Sciences, K. S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Namakkal District, Tamilnadu, 637215, India.
Department of Biotechnology, Vikrama Simhapuri University, Nellore, Andhra Pradesh, 524003, India.
Cardiovasc Toxicol. 2018 Jun;18(3):199-205. doi: 10.1007/s12012-017-9430-2.
Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation and their clearance by antioxidant protection systems. Transcription factor the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a significant role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. The Nrf2 plays a significant role in ARE-mediated basal and inducible expression of more than 200 genes that can be grouped into numerous categories as well as antioxidant genes and phase II detoxifying enzymes. On the other hand, activation of Nrf2 by natural and synthetic therapeutics or antioxidants has been revealed effective for the prevention and treatment of toxicities and diseases connected with oxidative stress. Hence, recently focus has been shifted toward plants and plant-based medicines in curing such chronic diseases, as they are supposed to be less toxic. In this review, we focused on the role of some natural products on diabetic cardiomyopathy through Nrf2 pathway.
糖尿病性心肌病是糖尿病患者的主要心脏并发症之一，其与氧化应激有关，这是由于活性氧（ROS）或/和活性氮（RNS）的产生与抗氧化保护系统清除之间的平衡被打破所致。转录因子红细胞生成素 2 相关因子 2（Nrf2）通过调节多种下游抗氧化剂在维持氧化平衡方面发挥着重要作用。Nrf2 在 ARE 介导的 200 多种基因的基础表达和诱导表达中发挥重要作用，这些基因可以分为许多类别，包括抗氧化基因和 II 相解毒酶。另一方面，通过天然和合成治疗剂或抗氧化剂激活 Nrf2 已被证明可有效预防和治疗与氧化应激相关的毒性和疾病。因此，最近的研究重点转向了植物和植物药在治疗此类慢性疾病方面的应用，因为它们的毒性可能较低。在这篇综述中，我们重点讨论了一些天然产物通过 Nrf2 通路在糖尿病性心肌病中的作用。
