Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Bone Mineral Research Center, Winthrop University Hospital, 222 Station Plaza North, Suite 510, Mineola, NY 11501, USA.
Endocrinol Metab Clin North Am. 2017 Dec;46(4):919-933. doi: 10.1016/j.ecl.2017.07.004. Epub 2017 Sep 28.
Recent understanding has highlighted the importance of extraskeletal role of vitamin D. Despite numerous observational and interventional studies over the last two decades, the apparent divergent clinical findings have intensified the controversy regarding this role of vitamin D in older adults. This article reviews the existing literature and summarizes the current knowledge of vitamin D status and vitamin D supplementation on falls and physical performance, describes the putative mechanisms underlying this association, and reflects on the controversy surrounding vitamin D recommendations in older adults.
最近的认识强调了维生素 D 的骨骼外作用的重要性。尽管在过去的二十年中进行了大量的观察性和干预性研究，但明显不同的临床发现加剧了关于维生素 D 在老年人中的这种作用的争议。本文回顾了现有文献，总结了目前关于维生素 D 状态和维生素 D 补充剂与跌倒和身体机能的关系的知识，描述了这种关联的潜在机制，并思考了老年人维生素 D 推荐方面的争议。
