Jiang Yunyi, Mei Yazhao, Tian Yuan, Shen Li, Xu Shuqin, Zhang Hao, Zhang Zhenlin
Department of Osteoporosis and Bone Disease, Shanghai Clinical Research Center of Bone Disease, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Clinical Research Center, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Nutr. 2024 Aug 5;11:1390668. doi: 10.3389/fnut.2024.1390668. eCollection 2024.
Studies on the baseline vitamin D levels in osteogenesis imperfecta (OI) patients before medication are scarce. This study assessed the vitamin D status of a population with OI at both the overall level and within different age groups. It correlated baseline 25-hydroxyvitamin D (25(OH)D) levels with other bone-related factors, biochemical markers, and bone density.
We collected 25(OH)D levels from 95 OI patients in East China (59 under 18 years old and 36 over 18 years old). Postmenopausal women and men over 50 years old are excluded. Measurements included body indicators, biochemical markers, and bone mineral density (BMD) assessed by Dual-energy X-ray absorptiometry (DXA). Data analysis was performed using SPSS 26.0.
In the overall population, among those under 18 years old, and among those over 18 years old, 87.4, 83.1, and 94.4%, respectively, were vitamin D deficient (<30 ng/mL), while 47.4, 40.7, and 58.3% had vitamin D deficiency (<20 ng/mL), respectively. In the overall population and among those under 18 years old, serum 25(OH)D levels were negatively correlated with age and parathyroid hormone (PTH) levels, and 25(OH)D levels (<10 ng/mL, 10-20 ng/mL, 20-30 ng/mL, >30 ng/mL) showed a negative correlation with BMI. In OI patients under 18 years old, serum 25(OH)D was negatively correlated with serum β-CTX levels. In adult male OI population, 25(OH)D levels were negatively correlated with OI severity (Type I, IV, III). No statistically significant correlation was found between 25(OH)D levels and BMD Z-scores.
This study on OI in East China reveals significant vitamin D insufficiency and deficiency in baseline levels among pediatric, adolescent and adult OI patients. It assesses the correlation of 25(OH)D levels with various influencing factors, providing crucial insights into understanding the impact of OI on vitamin D status across different age groups and aiding in better clinical management of OI patients.
关于成骨不全（OI）患者用药前基线维生素D水平的研究较少。本研究评估了一组OI患者在总体水平以及不同年龄组中的维生素D状况。它将基线25-羟基维生素D（25(OH)D）水平与其他骨相关因素、生化标志物和骨密度进行了关联分析。
我们收集了来自中国东部95例OI患者的25(OH)D水平（59例18岁以下，36例18岁以上）。排除绝经后女性和50岁以上男性。测量指标包括身体指标、生化标志物以及通过双能X线吸收法（DXA）评估的骨密度（BMD）。使用SPSS 26.0进行数据分析。
在总体人群、18岁以下人群和18岁以上人群中，维生素D缺乏（<30 ng/mL）的比例分别为87.4%、83.1%和94.4%，而维生素D严重缺乏（<20 ng/mL）的比例分别为47.4%、40.7%和58.3%。在总体人群和18岁以下人群中，血清25(OH)D水平与年龄和甲状旁腺激素（PTH）水平呈负相关，并且25(OH)D水平（<10 ng/mL、10 - 20 ng/mL、20 - 30 ng/mL、>30 ng/mL）与体重指数（BMI）呈负相关。在18岁以下的OI患者中，血清25(OH)D与血清β-CTX水平呈负相关。在成年男性OI人群中，25(OH)D水平与OI严重程度（I型、IV型、III型）呈负相关。未发现25(OH)D水平与BMD Z值之间存在统计学显著相关性。
这项针对中国东部OI患者的研究揭示了儿童、青少年和成年OI患者基线水平存在显著的维生素D不足和缺乏情况。它评估了25(OH)D水平与各种影响因素的相关性，为理解OI对不同年龄组维生素D状况的影响提供了关键见解，并有助于更好地对OI患者进行临床管理。
