作为一种理解中药草药治疗的机制方法，激效作用。
Hormesis as a mechanistic approach to understanding herbal treatments in traditional Chinese medicine.
机构信息
State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Post-doctoral Research Station, College of Civil Engineering, Tongji University, Shanghai 200092, China.
Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
出版信息
Pharmacol Ther. 2018 Apr;184:42-50. doi: 10.1016/j.pharmthera.2017.10.013. Epub 2017 Nov 8.
Traditional Chinese medicine (TCM) has been long practiced and is becoming ever more widely recognized as providing curative and/or healing treatments for a number of diseases and physiological conditions. This paper posits that herbal medicines used in TCM treatments may act through hormetic dose-response mechanisms. It is proposed that the stimulatory (i.e., low dose) and inhibitory (i.e., high dose) components of the hormetic dose response correspond to respective "regulating" and "curing" aspects of TCM herbal treatments. Specifically, the "regulating" functions promote adaptive or preventive responses, while "curing" treatments alleviate the clinical symptoms. Patterns of hormetic responses are described, and the applicability of these processes to herbal medicines of TCM are explicated. It is noted that a research agenda aimed at elucidating these mechanisms and patterns would be expansive and complex. However, we argue its value, in that hormesis may afford something akin to a Rosetta Stone with which to interpret, translate, and explain TCM herbology in ways that are aligned with biomedical perspectives that could enable a more integrative approach to medicine.
中医（TCM）长期以来一直被实践，并越来越被广泛认为可以为许多疾病和生理状况提供治疗和/或康复治疗。本文提出，TCM 治疗中使用的草药可能通过适应原剂量反应机制发挥作用。本文提出，适应原剂量反应的刺激（即低剂量）和抑制（即高剂量）成分分别对应 TCM 草药治疗的“调节”和“治疗”方面。具体来说，“调节”功能促进适应性或预防性反应，而“治疗”则缓解临床症状。本文描述了适应原反应的模式，并阐述了这些过程在 TCM 草药中的适用性。需要指出的是，阐明这些机制和模式的研究议程将是广泛而复杂的。然而，我们认为它具有价值，因为适应原可能提供一种类似罗塞塔石碑的工具，用于以与生物医学观点一致的方式解释、翻译和解释 TCM 草药学，从而能够采用更具整体性的医学方法。
Zotero 插件