Xu Guan-Ling, Xie Meng, Yang Xiao-Yan, Song Yan, Yan Cheng, Yang Yue, Zhang Xia, Liu Zi-Zhen, Tian Yu-Xin, Wang Yan, Jiang Rui, Liu Wei-Rui, Wang Xiao-Hong, She Gai-Mei
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China.
Pharmacy College, Ningxia Medical University, Ningxia 750000, China.
Molecules. 2014 Nov 4;19(11):17897-925. doi: 10.3390/molecules191117897.
Component fingerprints are a recognized method used worldwide to evaluate the quality of traditional Chinese medicines (TCMs). To foster the strengths and circumvent the weaknesses of the fingerprint technique in TCM, spectrum-effect relationships would complementarily clarify the nature of pharmacodynamic effects in the practice of TCM. The application of the spectrum-effect relationship method is crucial for understanding and interpreting TCM development, especially in the view of the trends towards TCM modernization and standardization. The basic requirement for using this method is in-depth knowledge of the active material basis and mechanisms of action. It is a novel and effective approach to study TCMs and great progress has been made, but to make it more accurate for TCM research purposes, more efforts are needed. In this review, the authors summarize the current knowledge about the spectrum-effect relationship method, including the fingerprint methods, pharmacodynamics studies and the methods of establishing relationships between the fingerprints and pharmacodynamics. Some speculation regarding future perspectives for spectrum-effect relationship approaches in TCM modernization and standardization are also proposed.
组分指纹图谱是一种在全球范围内被认可的用于评估中药质量的方法。为了发扬指纹图谱技术在中药领域的优势并规避其不足，谱效关系将在中药实践中互补性地阐明药效作用的本质。谱效关系方法的应用对于理解和阐释中药的发展至关重要，尤其是从中药现代化和标准化的趋势来看。使用该方法的基本要求是深入了解活性物质基础和作用机制。这是一种研究中药的新颖且有效的方法，并且已经取得了很大进展，但为了使其在中药研究目的上更加准确，还需要付出更多努力。在这篇综述中，作者总结了关于谱效关系方法的当前知识，包括指纹图谱方法、药效学研究以及建立指纹图谱与药效学之间关系的方法。还提出了一些关于谱效关系方法在中药现代化和标准化方面未来前景的推测。
