Seoudi Rania S, Mechler Adam
Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, 3086, Australia.
Adv Exp Med Biol. 2017;1030:51-94. doi: 10.1007/978-3-319-66095-0_4.
The ability to design functionalized peptide nanostructures for specific applications is tied to the ability of controlling the morphologies of the self-assembled superstructures. That, in turn, is based on a thorough understanding of the structural and environmental factors affecting self-assembly. The aim of designing self-assembling nanostructures of controlled geometries is achieved via a combination of directional and non-directional second order interactions. If the interactions are distributed in a geometrically defined way, a specific and selective supramolecular self-assembly motif is the result. In this chapter we detail the role of non-covalent interactions on the self-assembly of peptides; we will also discuss different types of peptide building blocks and design rules for engineering unnatural supramolecular structures.
设计用于特定应用的功能化肽纳米结构的能力与控制自组装超结构形态的能力相关。而这又基于对影响自组装的结构和环境因素的透彻理解。通过定向和非定向二阶相互作用的组合，实现了设计具有可控几何形状的自组装纳米结构的目标。如果相互作用以几何定义的方式分布，就会产生特定且选择性的超分子自组装基序。在本章中，我们详细阐述了非共价相互作用在肽自组装中的作用；我们还将讨论不同类型的肽构建块以及工程化非天然超分子结构的设计规则。
