Department of Endocrinology and Nutrition, Germans Trias i Pujol Research Institute, Barcelona, Spain and CIBER Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Spain.
Department of Biochemistry and Molecular Biomedicine. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain.
Int J Obes (Lond). 2018 Apr;42(4):919-922. doi: 10.1038/ijo.2017.268. Epub 2017 Oct 30.
Bariatric surgery is currently the most effective therapy for type 2 diabetes. However, the mechanisms underlying its beneficial effects remain elusive. Here we studied the effects of bariatric surgery on circulating meteorin-like (Metrnl) and oncostatin m (OSM) levels, two hormones intimately linked to energy homeostasis. Metrnl and OSM levels were assessed at baseline, 6 and 12 months after laparoscopic sleeve gastrectomy (LSG) in 25 patients with obesity, as well as in 33 normal-weight controls. At baseline, patients with obesity showed lower Metrnl and higher OSM levels compared to controls. LSG increased Metrnl and decreased OSM levels, in correlation to improvements in glucose and lipid homeostasis. Our data indicate that LSG conversely modulated Metrnl and OSM levels, and suggest that a dual approach modulating these two molecules might provide a novel strategy for obesity and type 2 diabetes treatment.
减重手术是目前治疗 2 型糖尿病最有效的方法。然而，其有益效果的机制仍难以捉摸。在这里，我们研究了减重手术对循环中脂肪素样（Metrnl）和抑瘤素 M（OSM）水平的影响，这两种激素与能量稳态密切相关。在腹腔镜袖状胃切除术（LSG）前、后 6 个月和 12 个月，我们评估了 25 例肥胖患者和 33 例体重正常对照者的 Metrnl 和 OSM 水平。在基线时，肥胖患者的 Metrnl 水平较低，OSM 水平较高。LSG 增加了 Metrnl 水平，降低了 OSM 水平，与葡萄糖和脂质稳态的改善相关。我们的数据表明，LSG 相反地调节了 Metrnl 和 OSM 水平，并表明这种双重方法调节这两种分子可能为肥胖和 2 型糖尿病的治疗提供一种新策略。
