Faculty of Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran.
Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):881-885. doi: 10.1016/j.dsx.2020.05.031. Epub 2020 May 21.
Sedentary behavior and/or physical inactivity are modifiable risk factors for noncommunicable diseases. Myokines are one of the mediators of physical activity health benefits. Relationship between regular physical activity (RPA) and baseline plasma Meteorin-Like Hormone (Metrnl) has not been explored in human. Hence, we compared baseline plasma Metrnl between sedentary individuals and ones with recreational physical activities, and role of Metrnl as a biological messenger between physical activity and insulin resistance and body composition was also explored.
Forty healthy young men (aged: 21 ± 2.1 yrs; BMI: 23 ± 3.44 kg/m) completed the study. Participants were equally assigned into two groups of control (sedentary) and case (recreational athletes). Baseline plasma Metrnl, glucose, insulin and body composition components and insulin resistance index (HOMA-IR) were assessed under resting conditions.
Except for baseline blood glucose, baseline plasma Metrnl, insulin, HOMA-IR and body mass index and body fat percentage were similar between two groups (P > 0.05). However, after Metrnl correction for the degree of insulin resistance index (Metrnl/HOMA-IR), recreational athletes showed a significantly greater baseline compared to sedentary subjects (P < 0.05). Baseline blood glucose showed a negative and significant correlation with baseline plasma Metrnl (P < 0.05).
Baseline plasma Metrnl is correlated with regular physical activity and insulin sensitivity, but not with body composition parameters. Metrnl may be one possible mediator of the beneficial effects of PA on insulin sensitivity in healthy humans. Hence, increasing awareness of the benefits of physical activity and incorporating physical activity into lifestyle are of great importance for people with non-communicable diseases.
久坐行为和/或身体活动不足是非传染性疾病的可改变危险因素。肌肉因子是身体活动健康益处的中介之一。在人类中，规律体力活动（RPA）与基线血浆 Meteorin 样激素（Metrnl）之间的关系尚未被探索。因此，我们比较了久坐个体和有娱乐性体力活动个体的基线血浆 Metrnl，还探索了 Metrnl 作为身体活动和胰岛素抵抗及身体成分之间的生物信使的作用。
40 名健康年轻男性（年龄：21±2.1 岁；BMI：23±3.44kg/m）完成了这项研究。参与者被平均分配到对照组（久坐）和病例组（娱乐性运动员）。在休息状态下评估基线血浆 Metrnl、血糖、胰岛素和身体成分成分以及胰岛素抵抗指数（HOMA-IR）。
除了基线血糖外，两组的基线血浆 Metrnl、胰岛素、HOMA-IR、体重指数和体脂百分比相似（P＞0.05）。然而，在 Metrnl 校正胰岛素抵抗指数（Metrnl/HOMA-IR）后，与久坐组相比，娱乐性运动员的基线水平显著更高（P＜0.05）。基线血糖与基线血浆 Metrnl 呈负相关（P＜0.05）。
基线血浆 Metrnl 与规律体力活动和胰岛素敏感性相关，但与身体成分参数无关。Metrnl 可能是 PA 对健康人群胰岛素敏感性有益影响的一个可能的中介。因此，提高对身体活动益处的认识并将身体活动纳入生活方式对非传染性疾病患者非常重要。
