Delfan Maryam, Radkia Fatemeh, Juybari Raheleh Amadeh, Daneshyar Saeed, Willems Mark Et, Saeidi Ayoub, Hackney Anthony C, Laher Ismail, Zouhal Hassane
Department of Exercise Physiology, Faculty of Sport Sciences, Alzahra University, Tehran, Iran.
Department of Physical Education, Hamedan University of Technology, Hamedan, Iran.
Curr Dev Nutr. 2024 Jul 25;8(9):104428. doi: 10.1016/j.cdnut.2024.104428. eCollection 2024 Sep.
Dysregulation of adipocyte function occurs in obesity. Meteorin-like protein (Metrnl) is a newly discovered modulator of inflammation, metabolism, and differentiation of human adipocytes. The dietary supplement Chlorella Vulgaris (CV) reduces hyperlipidemia, hyperglycemia, and oxidative stress in clinical trials.
To explore the impact of 12 wks of interval resistance training (IRT) and CV supplementation on plasma levels of Metrnl and oxidative stress in males with obesity.
Forty-four obese men (BMI: 32.0 ± 1.5 kg/m, weight: 101.1 ± 2.2 kg, age: 23-35 years) were randomly assigned into 4 groups ( = 11/group): control (CON), CV supplement (CV), IRT, and CV + IRT (CVIRT). The IRT was performed for 12 wks (3 sessions per week). The treatment consisted of a daily intake of CV (1800 mg capsule) or placebo capsules. Blood samples were collected 48 hours before and after the interventions to analyze biomedical measurements.
The IRT and CVIRT groups had elevations in plasma Metrnl, superoxide dismutase, and total antioxidant capacity levels (all < 0.0001), and reductions in malondialdehyde ( < 0.0001). Supplementation with CV significantly reduced malondialdehyde ( < 0.001) and increased total antioxidant capacity ( < 0.0001) but failed to alter superoxide dismutase or Metrnl ( > 0.05).
Although IRT and its combination with CV hold promise for improving Metrnl levels and oxidative status in obesity, combining IRT and CV do not yield greater benefits than IRT alone. Although standalone CV supplementation could favorably impact certain markers of oxidative stress, the effectiveness of CV supplementation appears to have a relatively limited effect across assessed biomarkers and requires further investigation.
肥胖时脂肪细胞功能失调。流星样蛋白（Metrnl）是新发现的人类脂肪细胞炎症、代谢及分化的调节因子。在临床试验中，膳食补充剂普通小球藻（CV）可降低高脂血症、高血糖和氧化应激。
探讨12周的间歇抗阻训练（IRT）及补充CV对肥胖男性血浆Metrnl水平及氧化应激的影响。
44名肥胖男性（BMI：32.0±1.5kg/m²，体重：101.1±2.2kg，年龄：23 - 35岁）被随机分为4组（每组n = 11）：对照组（CON）、补充CV组（CV）、IRT组和CV + IRT组（CVIRT）。IRT进行12周（每周3次）。治疗方案为每日服用CV（1800mg胶囊）或安慰剂胶囊。在干预前后48小时采集血样以分析生物医学指标。
IRT组和CVIRT组血浆Metrnl、超氧化物歧化酶及总抗氧化能力水平升高（均P < 0.0001），丙二醛降低（P < 0.0001）。补充CV显著降低丙二醛（P < 0.001）并增加总抗氧化能力（P < 0.0001），但未改变超氧化物歧化酶或Metrnl水平（P > 0.05）。
尽管IRT及其与CV联合使用有望改善肥胖患者的Metrnl水平和氧化状态，但联合使用IRT和CV并不比单独使用IRT带来更大益处。虽然单独补充CV可对氧化应激的某些指标产生有利影响，但补充CV的有效性在评估的生物标志物中似乎作用相对有限，需要进一步研究。
