靶向WNT信号通路用于多方面的胶质母细胞瘤治疗

McCord Matthew, Mukouyama Yoh-Suke, Gilbert Mark R, Jackson Sadhana

Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, United States.

Laboratory of Stem Cell and Neuro-Vascular Biology, Genetic and Developmental Biology Center, National Heart, Lung and Blood Institute, Bethesda, MD, United States.

Front Cell Neurosci. 2017 Oct 13;11:318. doi: 10.3389/fncel.2017.00318. eCollection 2017.

The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculature. We summarize the role of WNT in CNS development and describe how WNT signaling makes key contributions to malignant glioma stemness, invasiveness, therapeutic resistance, and angiogenesis. The role of WNT in these mechanisms, along with creation and maintainance of the blood-brain barrier (BBB), points to the potential of WNT as a multi-faceted target in malignant glioma therapy.

几十年来，WNT信号通路一直是发育生物学家非常感兴趣的领域，最近它已成为癌症生物学研究的核心主题。它对于许多器官系统的细胞生长和胚胎发育调节至关重要，尤其是中枢神经系统及其相关脉管系统。我们总结了WNT在中枢神经系统发育中的作用，并描述了WNT信号如何对恶性胶质瘤的干性、侵袭性、治疗抗性和血管生成做出关键贡献。WNT在这些机制中的作用，以及血脑屏障（BBB）的形成和维持，表明WNT在恶性胶质瘤治疗中作为多方面靶点的潜力。