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运用行为表观遗传学原理推动早期生活应激研究

Using Principles of Behavioral Epigenetics to Advance Research on Early-Life Stress.

作者信息

Conradt Elisabeth

机构信息

The University of Utah.

出版信息

Child Dev Perspect. 2017 Jun;11(2):107-112. doi: 10.1111/cdep.12219. Epub 2017 Jan 25.

DOI:10.1111/cdep.12219
PMID:29081832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5658048/
Abstract

While the negative effects of early-life stress on children's developmental outcomes are well documented, we know little about how these processes unfold and which children are more susceptible to these exposures. In this article, I outline how studying the effects of early-life stress on children's development can be advanced by considering how epigenetic processes may contribute to the emergence of children's behavior. The study of epigenetics can help pinpoint the mechanisms by which early-life stress may affect developmental outcomes and identify which children may be most sensitive to the effects of these exposures. I conclude by highlighting the challenges inherent in studying epigenetics in children and offer possible solutions.

摘要

虽然早年压力对儿童发展结果的负面影响已有充分记录，但我们对这些过程如何展开以及哪些儿童更容易受到这些影响知之甚少。在本文中，我概述了通过考虑表观遗传过程如何可能促成儿童行为的出现，来推进对早年压力对儿童发展影响的研究。表观遗传学研究有助于查明早年压力可能影响发展结果的机制，并确定哪些儿童可能对这些影响最为敏感。我在结尾强调了在儿童中研究表观遗传学所固有的挑战，并提供了可能的解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec81/5658048/0264ec99a847/nihms881022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec81/5658048/ede5f160e488/nihms881022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec81/5658048/0264ec99a847/nihms881022f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec81/5658048/ede5f160e488/nihms881022f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec81/5658048/0264ec99a847/nihms881022f2.jpg

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本文引用的文献

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Dev Psychopathol. 2016 Nov;28(4pt2):1421-1430. doi: 10.1017/S0954579416000183. Epub 2016 Apr 4.
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Methylation of the Glucocorticoid Receptor Gene Promoter in Preschoolers: Links With Internalizing Behavior Problems.学龄前儿童糖皮质激素受体基因启动子的甲基化：与内化行为问题的关联
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The Contributions of Maternal Sensitivity and Maternal Depressive Symptoms to Epigenetic Processes and Neuroendocrine Functioning.母亲敏感性和母亲抑郁症状对表观遗传过程及神经内分泌功能的影响
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