Ustaoglu Melih, Solmaz Nilgun, Onder Feyza
Sisli Hamidiye Etfal Training and Research Hospital, Ophthalmology Clinic, Istanbul, Turkey.
Haseki Training and Research Hospital, Ophthalmology Clinic, Istanbul, Turkey.
GMS Ophthalmol Cases. 2017 Oct 25;7:Doc28. doi: 10.3205/oc000079. eCollection 2017.
To present the successful outcome of regenerating agent (RGTA) treatment in a patient with severe ocular surface chemical injury. Case report A 14-year-old female patient was admitted to our clinic following chemical burn in the left eye. Her best corrected visual acuity (BCVA) was 20/40; and she had total corneal and 75% conjunctival epithelial loss, corneal haze, and limbal ischemia for nine clock hours in the left eye. The patient had already received standard therapy consisting of patching, preservative-free artificial tears, topical netilmicin, topical dexamethasone, oral doxycycline, and vitamin C for two weeks. We initially cleaned the conjunctival necrotic tissues, applied the silicon hydrogel bandage contact lens, exchanged the topical netilmicin with preservative-free moxifloxacin and supplemented this therapy with RGTA (Cacicol20, Paris, France) once in two days. The BCVA of the patient improved to 20/20 and the ocular surface re-epithelization was completed on day 20. RGTAs are effective biological agents for the treatment of corneal epithelial defects following severe ocular surface chemical injuries.
介绍再生剂（RGTA）治疗严重眼表化学伤患者的成功结果。病例报告 一名14岁女性患者因左眼化学烧伤入院。她的最佳矫正视力（BCVA）为20/40；左眼角膜完全上皮缺失，结膜上皮缺失75%，角膜混浊，角膜缘缺血达9个钟点。患者已接受包括眼部包扎、无防腐剂人工泪液、局部用奈替米星、局部用地塞米松、口服多西环素和维生素C在内的标准治疗两周。我们首先清理结膜坏死组织，应用硅水凝胶绷带式隐形眼镜，将局部用奈替米星换成无防腐剂的莫西沙星，并每两天用RGTA（法国巴黎的Cacicol20）补充一次该治疗。患者的BCVA提高到20/20，眼表在第20天完成重新上皮化。RGTA是治疗严重眼表化学伤后角膜上皮缺损的有效生物制剂。
