Helseth E, Unsgaard G, Dalen A, Fure H, Skandsen T, Odegaard A, Vik R
Department of Neurosurgery, University Hospital of Trondheim, Norway.
Br J Neurosurg. 1988;2(2):217-25. doi: 10.3109/02688698808992672.
Amplification and overexpression of proto-oncogenes are associated with the malignant nature of some human tumours. In this study we have determined the prevalence of amplification of the proto-oncogenes c-erb B1 (= epidermal growth factor receptor gene), c-erb B2 and c-myc in 44 human intracranial tumours (27 gliomas, six metastases to the brain and 11 meningiomas). None of the tumours had an amplified c-erb B2 gene and only two tumours had an amplified c-myc gene. Nineteen per cent (five out of 27) of the gliomas, 50% (three out of six) of the brain metastases and 0% (0 out of 11) meningiomas had an amplified EGF-receptor gene. Amplification of the EGF-receptor gene appeared to give a growth advantage when single-cell suspensions of the tumours were grown in agarose.
原癌基因的扩增和过表达与某些人类肿瘤的恶性性质相关。在本研究中，我们测定了原癌基因c-erb B1（=表皮生长因子受体基因）、c-erb B2和c-myc在44例人类颅内肿瘤（27例胶质瘤、6例脑转移瘤和11例脑膜瘤）中的扩增发生率。没有肿瘤具有扩增的c-erb B2基因，只有2例肿瘤具有扩增的c-myc基因。19%（27例中的5例）的胶质瘤、50%（6例中的3例）的脑转移瘤和0%（11例中的0例）的脑膜瘤具有扩增的表皮生长因子受体基因。当肿瘤的单细胞悬液在琼脂糖中生长时，表皮生长因子受体基因的扩增似乎赋予了生长优势。
