Libermann T A, Nusbaum H R, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield M D, Ullrich A, Schlessinger J
J Cell Sci Suppl. 1985;3:161-72. doi: 10.1242/jcs.1985.supplement_3.16.
The expression of epidermal growth factor (EGF) receptor in brain tumours of glial origin was studied at the protein, mRNA and genomic levels. Four out of 10 glioblastomas that overexpress EGF receptor also have gene amplification. The amplified genes appear to be rearranged, generating an aberrant mRNA in at least one of these tumours. Such receptor defects may be relevant to tumorigenesis of human glioblastomas.
在蛋白质、mRNA和基因组水平研究了胶质来源脑肿瘤中表皮生长因子（EGF）受体的表达。10例过表达EGF受体的胶质母细胞瘤中有4例也存在基因扩增。扩增的基因似乎发生了重排，在这些肿瘤中至少有1例产生了异常mRNA。这种受体缺陷可能与人类胶质母细胞瘤的肿瘤发生有关。
