Liu Yun, Wang Wenhui, Han Junwen, Sun Jinwei
Jiangsu Key Laboratory of Green Synthesis for Functional Materials and School of Chemistry and Material Science, Jiangsu Normal University, Xuzhou 221116, Jiangsu, P. R. China.
Org Biomol Chem. 2017 Nov 15;15(44):9311-9318. doi: 10.1039/c7ob02014g.
A copper-promoted cascade decarboxylative halogenation and oxidative diamination reaction sequence of 2-aminopyridines with alkynoic acids has been developed for the synthesis of 2-haloimidazo[1,2-a]pyridines. In this reaction, two C-N bonds and one C-halogen bond are formed in one pot, generating the desired products in good yields. This is the first report on the synthesis of 2-haloimidazo[1,2-a]pyridine derivatives from alkynoic acids.
已开发出一种铜促进的2-氨基吡啶与炔酸的串联脱羧卤化和氧化双胺化反应序列，用于合成2-卤代咪唑并[1,2-a]吡啶。在该反应中，一锅法形成了两个C-N键和一个C-卤键，以良好的产率生成所需产物。这是关于从炔酸合成2-卤代咪唑并[1,2-a]吡啶衍生物的首次报道。
