Emokpae Mathias Abiodun, Aruomaren Austin, Osime Evarista
Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin 300001, Nigeria.
Med Sci (Basel). 2016 Jul 29;4(3):11. doi: 10.3390/medsci4030011.
The renal functions and structure in sickle cell anaemia (SCA) patients may be affected by chronic haemodynamic changes and consequences of vaso-occlusive events in the renal medulla. Few reports on neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in SCA patients in Africans exist in the literature. This study correlates the values of NLR and PLR with measured traditional inflammatory markers in SCA patients with and without proteinuria and impaired kidney function (defined in this study as estimated glomerular filtration rate (eGFR), less than 60 mL/min/1.73 m². Full blood count, C-reactive protein (CRP), and fibrinogen were assayed in 150 SCA patients and 50 control subjects using Coulter Haematology analyser (CELL DYE 37000) and ELISA method, respectively. The NLR and PLR were calculated by dividing absolute neutrophil or platelet counts by absolute lymphocyte count. Fibrinogen, CRP, NLR, and PLR increased progressively ( 0.001) in SCA patients with or without proteinuria, with the highest values seen in those with impaired renal function. NLR correlated positively with CRP and fibrinogen in SCA patients without proteinuria ( 0.001), with proteinuria ( 0.001), and impaired renal function ( 0.05). A positive relationship was also observed between NLR and fibrinogen in the control subjects. The need to determine cut-off values for these leukocyte ratios to be used in identifying those patients at risk and in the general management of SCA patients is suggested.
镰状细胞贫血（SCA）患者的肾功能和结构可能会受到慢性血流动力学变化以及肾髓质血管闭塞事件后果的影响。关于非洲SCA患者中性粒细胞与淋巴细胞（NLR）及血小板与淋巴细胞（PLR）比值的报道在文献中较少。本研究将NLR和PLR值与有或无蛋白尿及肾功能受损（本研究定义为估计肾小球滤过率（eGFR）低于60 mL/min/1.73 m²）的SCA患者所测得的传统炎症标志物进行关联分析。分别使用库尔特血液分析仪（CELL DYE 37000）和ELISA法对150例SCA患者和50例对照者进行全血细胞计数、C反应蛋白（CRP）和纤维蛋白原检测。NLR和PLR通过将绝对中性粒细胞或血小板计数除以绝对淋巴细胞计数来计算。有或无蛋白尿的SCA患者中，纤维蛋白原、CRP、NLR和PLR均呈逐渐升高趋势（P<0.001），肾功能受损者的值最高。在无蛋白尿的SCA患者中（P<0.001）、有蛋白尿的患者中（P<0.001）以及肾功能受损的患者中（P<0.05），NLR与CRP和纤维蛋白原呈正相关。在对照者中，NLR与纤维蛋白原之间也观察到正相关关系。建议确定这些白细胞比值的临界值，以用于识别有风险的患者以及SCA患者的总体管理。
