Svardal Hannes, Jasinska Anna J, Apetrei Cristian, Coppola Giovanni, Huang Yu, Schmitt Christopher A, Jacquelin Beatrice, Ramensky Vasily, Müller-Trutwin Michaela, Antonio Martin, Weinstock George, Grobler J Paul, Dewar Ken, Wilson Richard K, Turner Trudy R, Warren Wesley C, Freimer Nelson B, Nordborg Magnus
Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter (VBC), Vienna, Austria.
Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, California, USA.
Nat Genet. 2017 Dec;49(12):1705-1713. doi: 10.1038/ng.3980. Epub 2017 Oct 30.
Vervet monkeys are among the most widely distributed nonhuman primates, show considerable phenotypic diversity, and have long been an important biomedical model for a variety of human diseases and in vaccine research. Using whole-genome sequencing data from 163 vervets sampled from across Africa and the Caribbean, we find high diversity within and between taxa and clear evidence that taxonomic divergence was reticulate rather than following a simple branching pattern. A scan for diversifying selection across taxa identifies strong and highly polygenic selection signals affecting viral processes. Furthermore, selection scores are elevated in genes whose human orthologs interact with HIV and in genes that show a response to experimental simian immunodeficiency virus (SIV) infection in vervet monkeys but not in rhesus macaques, suggesting that part of the signal reflects taxon-specific adaptation to SIV.
绿猴是分布最广泛的非人类灵长类动物之一，表现出相当大的表型多样性，长期以来一直是多种人类疾病和疫苗研究的重要生物医学模型。利用从非洲和加勒比地区采集的163只绿猴的全基因组测序数据，我们发现类群内部和类群之间存在高度多样性，并有明确证据表明分类学上的分歧是网状的，而不是遵循简单的分支模式。对各分类群进行的多样化选择扫描识别出影响病毒过程的强烈且高度多基因的选择信号。此外，在其人类直系同源基因与HIV相互作用的基因以及在绿猴而非恒河猴中对实验性猴免疫缺陷病毒（SIV）感染有反应的基因中，选择分数升高，这表明部分信号反映了对SIV的分类群特异性适应。
