Allergy and Clinical Immunology, Department Medical Sciences, University of Torino, Torino, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Allergy. 2018 Apr;73(4):958-961. doi: 10.1111/all.13344. Epub 2017 Nov 22.
Anaphylaxis is a serious systemic allergic reaction with rapid onset and potentially life-threatening. We report in detail a case of severe nocturnal anaphylaxis due to pigeon tick bite showing the diagnostic value of the extract and the recombinant allergen in the diagnostic procedures (basophil activation test, IgE immunoblot, and experimental ImmunoCAP). Apart from the presented case, we describe that during the last 10 years, we have collected 28 cases of allergy to Argas reflexus from several European countries. We suspect that this allergy is underdiagnosed because of the lack of diagnostic reagents. Because of the growing number of pigeons in Middle and Southern Europe cities, some cases of idiopathic anaphylaxis could potentially be caused by A. reflexus in those countries. The identification of pigeon ticks as a trigger of anaphylaxis would greatly improve medical care and advice for these patients as the parasite can be exterminated by eradication measures to avoid further incidents.
过敏反应是一种严重的全身性过敏反应，发病迅速，可能危及生命。我们详细报告了一例因鸽子蜱叮咬引起的严重夜间过敏反应，该病例显示了提取物和重组变应原在诊断程序（嗜碱性粒细胞激活试验、IgE 免疫印迹和实验性 ImmunoCAP）中的诊断价值。除了所报告的病例外，我们还描述了在过去 10 年中，我们从几个欧洲国家收集了 28 例对 Argas reflexus 的过敏病例。我们怀疑由于缺乏诊断试剂，这种过敏反应被漏诊了。由于中南部欧洲城市鸽子数量的增加，一些特发性过敏反应的病例在这些国家可能是由 A. reflexus 引起的。将鸽子蜱鉴定为过敏反应的触发因素将极大地改善这些患者的医疗和咨询服务，因为可以通过根除措施消灭寄生虫，以避免进一步发生此类事件。
