Yu Qinyuan, Han Wenzhong, Zhu Yixi, Zhai Hua
Shanghai Sunshine Rehabilitation Center (Yangzhi Affiliated Rehabilitation Hospital of Tongji University), Shanghai, China.
Shanghai Songjiang Central Hospital, Shanghai, China.
Pak J Pharm Sci. 2017 Sep;30(5(Special)):1899-1903.
In recent years, the antioxidant efficacy of puerarin has been recognized. However, there is less research on Puerarin used in diabetes. This paper analyzes the effect of puerarin on type II diabetes mellitus induced by streptozotocin combined with orthopaedic footwear. In this study, 80 Sprague Dawley (SD) rats were fed with high fat and high sucrose diet for one month, and 1% streptozotocin (STZ) was used to induce type II diabetes mellitus. After 6 weeks aerobic exercise and puerarin intervention in rats, the effect of aerobic exercise and puerarin intervention on antioxidant ability in diabetic rats was investigated. The results showed that aerobic exercise and puerarin intervention can improve the insulin resistance in rats. Meanwhile, the annual incidence of foot ulcers in diabetic patients is 2%, while orthopaedic footwear can reduce the probability of diabetic foot ulcers. In general, exercise and puerarin intervention can really play a role in the prevention and treatment of diabetes, such as improving the metabolic status of diabetic patients and reducing their dependence on drugs.
近年来，葛根素的抗氧化功效已得到认可。然而，关于葛根素用于糖尿病方面的研究较少。本文分析了葛根素对链脲佐菌素联合矫形鞋诱导的II型糖尿病的影响。在本研究中，80只Sprague Dawley（SD）大鼠用高脂肪高蔗糖饮食喂养1个月，并用1%链脲佐菌素（STZ）诱导II型糖尿病。对大鼠进行6周有氧运动和葛根素干预后，研究有氧运动和葛根素干预对糖尿病大鼠抗氧化能力的影响。结果表明，有氧运动和葛根素干预可改善大鼠的胰岛素抵抗。同时，糖尿病患者足部溃疡的年发病率为2%，而矫形鞋可降低糖尿病足溃疡的发生率。总体而言，运动和葛根素干预在糖尿病的防治中确实能发挥作用，如改善糖尿病患者的代谢状况并减少他们对药物的依赖。
