核糖体 S10 基因在对替加环素敏感性降低的金黄色葡萄球菌临床株中的突变。
Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline.
机构信息
National Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium
National Reference Centre-Staphylococcus aureus, Department of Microbiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
出版信息
Antimicrob Agents Chemother. 2017 Dec 21;62(1). doi: 10.1128/AAC.01852-17. Print 2018 Jan.
Abstract
Mutations on the tip of the extended loop of the ribosomal S10 protein have been associated to tigecycline (TGC) resistance in passaged mutants of different bacteria species. This study described the first two clinical TGC-resistant isolates with these mutations. One strain (TGC MIC = 2 mg/liter) had a 12-nucleotide deletion affecting residues 56 to 59 (HKYK) of the S10 protein. The second strain (TGC MIC = 1 mg/liter) had amino acid substitutions (K57M and Y58F) previously described in passaged mutants.
摘要
核糖体 S10 蛋白延伸环尖端的突变与不同细菌种属传代突变株中的替加环素（TGC）耐药性有关。本研究描述了这两种具有这些突变的首个临床 TGC 耐药分离株。一株（TGC MIC = 2 毫克/升）的 S10 蛋白有影响残基 56 到 59（HKYK）的 12 个核苷酸缺失。第二株（TGC MIC = 1 毫克/升）的氨基酸取代（K57M 和 Y58F）之前在传代突变株中已有描述。
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