Department of Neurology, Saarland University Medical Center, Homburg, Germany.
Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale, Novara, Italy.
Dis Markers. 2017;2017:5434310. doi: 10.1155/2017/5434310. Epub 2017 Sep 11.
To investigate the relationship between optic nerve sheath diameter, optic nerve diameter, visual acuity and osteopontin, and neurofilament heavy chain in patients with acute optic neuritis.
Sonographic and visual acuity assessment and biomarker measurements were executed in 23 patients with unilateral optic neuritis and in 19 sex- and age-matched healthy controls.
ONSD was thicker on the affected side at symptom onset (median 6.3 mm; interquartile range 6.0-6.5) than after 12 months (5.3 mm; 4.9-5.6; < 0.001) or than in controls (5.2 mm; 4.8-5.5; < 0.001). OND was significantly increased in the affected side (3.4 mm; 2.9-3.8) compared to healthy controls (2.7 mm; 2.5-2.9; < 0.001) and was thicker at baseline than after 12 months (2.8 mm; 2.7-3.0; < 0.01). Visual acuity improved significantly after 12 months (1.00; 0.90-1.00) compared to onset of symptoms (0.80; 0.40-1.00; < 0.001). OPN levels were significantly higher in patients at presentation (median 6.44 ng/ml; 2.05-10.06) compared to healthy controls (3.21 ng/ml, 1.34-4.34; < 0.03). Concentrations of NfH were significantly higher in patients than in controls.
ONSD and OND are increased in the affected eye. OPN and NfH are elevated in patients, confirming the presence of any underlying inflammation and axonal injury.
探讨急性视神经炎患者视神经鞘直径、视神经直径、视力与骨桥蛋白和神经丝重链之间的关系。
对 23 例单侧视神经炎患者和 19 例性别和年龄匹配的健康对照者进行了超声检查、视力评估和生物标志物测量。
在症状发作时（中位数 6.3mm；四分位距 6.0-6.5），患侧视神经鞘直径（ONSD）明显大于 12 个月后（5.3mm；4.9-5.6；<0.001）或对照组（5.2mm；4.8-5.5；<0.001）。患侧视神经直径（OND）明显大于健康对照组（3.4mm；2.9-3.8）（<0.001），且在基线时比 12 个月后更厚（2.8mm；2.7-3.0；<0.01）。与症状发作时相比（0.80；0.40-1.00），12 个月后视力明显改善（1.00；0.90-1.00；<0.001）。与健康对照组相比（3.21ng/ml，1.34-4.34；<0.03），患者就诊时 OPN 水平明显更高（中位数 6.44ng/ml；2.05-10.06）。患者的 NfH 浓度明显高于对照组。
患侧的 ONSD 和 OND 增加。OPN 和 NfH 在患者中升高，证实了潜在炎症和轴突损伤的存在。
