Stibitz S, Aaronson W, Monack D, Falkow S
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD.
Tokai J Exp Clin Med. 1988;13 Suppl:223-6.
By a phenomenon known as phase-variation Bordetella pertussis is capable of changing between a virulent-phase in which multiple virulence-associated determinants are expressed, and an avirulent-phase in which the virulence-associated determinants are not expressed. Mutations in the vir locus of B. pertussis have a similar effect. We have examined the state of the vir locus in each of a series of strains derived one from the other by phase-variation. We have found that a single base-pair change is associated with the change between the virulent and avirulent phases. This single base-pair change corresponds to a frameshift mutation in the vir locus.
通过一种称为相变的现象，百日咳博德特氏菌能够在表达多种毒力相关决定因素的致病阶段和不表达毒力相关决定因素的无毒阶段之间转变。百日咳博德特氏菌毒力基因座的突变也有类似的效果。我们研究了通过相变从彼此衍生而来的一系列菌株中每个菌株的毒力基因座状态。我们发现，单个碱基对的变化与致病阶段和无毒阶段之间的变化相关。这个单个碱基对的变化对应于毒力基因座中的移码突变。
