Perdomo-Celis Federico, Taborda Natalia Andrea, Rugeles María Teresa
Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Medellín, Colombia.
Grupo de Investigaciones Biomédicas Uniremington, Programa de Medicina, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellín, Colombia.
Front Immunol. 2017 Sep 29;8:1241. doi: 10.3389/fimmu.2017.01241. eCollection 2017.
The lymphoid follicle is critical for the development of humoral immune responses. Cell circulation to this site is highly regulated by the differential expression of chemokine receptors. This feature contributes to the establishment of viral reservoirs in lymphoid follicles and the development of some types of malignancies that are able to evade immune surveillance, especially conventional CD8 T cells. Interestingly, a subtype of CD8 T cells located within the lymphoid follicle (follicular CD8 T cells) was recently described; these cells have been proposed to play an important role in viral and tumor control, as well as to modulate humoral and T follicular helper cell responses. In this review, we summarize the knowledge on this novel CD8 T cell population, its origin, function, and potential role in health and disease, in particular, in the context of the infection by the human immunodeficiency virus.
淋巴滤泡对于体液免疫反应的发展至关重要。细胞向该部位的循环受到趋化因子受体差异表达的高度调控。这一特性有助于在淋巴滤泡中建立病毒储存库，并促成某些能够逃避免疫监视（尤其是传统CD8 T细胞的免疫监视）的恶性肿瘤的发展。有趣的是，最近发现了位于淋巴滤泡内的一种CD8 T细胞亚型（滤泡性CD8 T细胞）；有人提出这些细胞在病毒和肿瘤控制中发挥重要作用，以及调节体液和滤泡辅助性T细胞反应。在这篇综述中，我们总结了关于这一新的CD8 T细胞群体的知识，包括其起源、功能以及在健康和疾病中的潜在作用，特别是在人类免疫缺陷病毒感染的背景下。
