Wang Yushi, Feng Xiaoxing, Shen Botao, Ma Jing, Zhao Waiou
Cardiovascular Center, The First Hospital of Jilin University, Changchun, China.
Front Genet. 2017 Oct 6;8:126. doi: 10.3389/fgene.2017.00126. eCollection 2017.
Vascular amyloidosis (VA) is a component of aging, but both VA and aging move forward together. Although, not all age-related molecules are involved with VA, some molecules are involved in a crosstalk between both of them. However, the cellular mechanism by which, vascular cells are phenotypically shifted to arterial remodeling, is not only involved in aging but also linked to VA. Additionally, patients with hypertension and atherosclerosis are susceptible to VA, while amyloidosis alone may provide fertile soil for the initiation and progression of subsequent hypertension and atherosclerosis. It is known that hypertension, atherosclerosis and amyloidosis can be viewed as accelerated aging. This review summarizes the available experimental and clinical evidence to help the reader to understand the advance and underlying mechanisms for VA involvement in and interaction with aging. Taken together, it is clear that VA, hypertension and atherosclerosis are closely intertwined with arterial aging as equal partners.
血管淀粉样变性（VA）是衰老的一个组成部分，但VA和衰老共同发展。虽然并非所有与年龄相关的分子都与VA有关，但一些分子参与了两者之间的相互作用。然而，血管细胞表型转变为动脉重塑的细胞机制不仅与衰老有关，还与VA有关。此外，高血压和动脉粥样硬化患者易患VA，而单独的淀粉样变性可能为后续高血压和动脉粥样硬化的发生和发展提供沃土。众所周知，高血压、动脉粥样硬化和淀粉样变性可被视为加速衰老。本综述总结了现有的实验和临床证据，以帮助读者理解VA参与衰老及与衰老相互作用的进展和潜在机制。综上所述，很明显VA、高血压和动脉粥样硬化作为同等因素与动脉衰老密切相关。
