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Resistance to docetaxel-induced apoptosis in prostate cancer cells by p38/p53/p21 signaling.p38/p53/p21 信号通路介导前列腺癌细胞对多西紫杉醇诱导凋亡的抵抗作用。
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Role of the Akt/mTOR survival pathway in cisplatin resistance in ovarian cancer cells.Akt/mTOR 生存通路在卵巢癌细胞顺铂耐药中的作用。
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Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.通过CDK1和CDK2活性预测人乳腺癌细胞对紫杉醇的敏感性。
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Maspin overexpression correlates with positive response to primary chemotherapy in ovarian cancer patients.在卵巢癌患者中，maspin过表达与对原发性化疗的阳性反应相关。
Gynecol Oncol. 2009 Apr;113(1):91-8. doi: 10.1016/j.ygyno.2008.12.038. Epub 2009 Feb 3.
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MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: preliminary evidence.MASPIN在接受原发性化疗（卡铂加长春瑞滨）和放疗的晚期头颈癌患者中的预后作用：初步证据。
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Differential sensitivity of human glioblastoma LN18 (PTEN-positive) and A172 (PTEN-negative) cells to Taxol for apoptosis.人胶质母细胞瘤 LN18（PTEN 阳性）和 A172（PTEN 阴性）细胞对紫杉醇诱导凋亡的敏感性差异。
Brain Res. 2008 Nov 6;1239:216-25. doi: 10.1016/j.brainres.2008.08.075. Epub 2008 Sep 4.
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Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms.抑癌基因PTEN对人卵巢癌细胞系顺铂耐药性的影响及相关机制
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PTEN/maspin信号通路对前列腺癌细胞中紫杉醇敏感性的调控

Regulation of paclitaxel sensitivity in prostate cancer cells by PTEN/maspin signaling.

作者信息

Gan Yu, Chen Qing, Lei Yan

机构信息

Qingshan Clinic, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

出版信息

Oncol Lett. 2017 Oct;14(4):4977-4982. doi: 10.3892/ol.2017.6793. Epub 2017 Aug 23.

DOI:10.3892/ol.2017.6793
PMID:29085510
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5649693/
Abstract

Taxol is the first-line chemotherapeutic agent for patients with castration-resistant prostate cancer. However, the mechanism of the sensitivity of prostate cancer cells to Taxol treatment remains to be elucidated. In the present study, it was found that paclitaxel induced more apoptosis and maspin expression in phosphatase and tensin homolog (PTEN)-positive 22Rv1 cells than PTEN-negative LNCaP cells. Knockdown of PTEN in 22Rv1 cells resulted in increased resistance to paclitaxel and impaired the induction of maspin expression by paclitaxel. Overexpression of PTEN sensitized LNCaP cells to paclitaxel treatment and increased maspin induction by paclitaxel. Furthermore, knocking down maspin abrogated PTEN-induced paclitaxel sensitivity in LNCaP cells. PTEN/maspin signaling may be important for regulating the susceptibility to paclitaxel in prostate cancer.

摘要

紫杉醇是去势抵抗性前列腺癌患者的一线化疗药物。然而，前列腺癌细胞对紫杉醇治疗敏感性的机制仍有待阐明。在本研究中，发现紫杉醇在磷酸酶和张力蛋白同源物（PTEN）阳性的22Rv1细胞中比PTEN阴性的LNCaP细胞诱导更多的细胞凋亡和maspin表达。在22Rv1细胞中敲低PTEN导致对紫杉醇的抗性增加，并削弱了紫杉醇对maspin表达的诱导作用。PTEN的过表达使LNCaP细胞对紫杉醇治疗敏感，并增加了紫杉醇对maspin的诱导作用。此外，敲低maspin消除了PTEN诱导的LNCaP细胞对紫杉醇的敏感性。PTEN/maspin信号传导可能对调节前列腺癌对紫杉醇的敏感性很重要。