Bennike Tue Bjerg, Carlsen Thomas Gelsing, Ellingsen Torkell, Bonderup Ole Kristian, Glerup Henning, Bøgsted Martin, Christiansen Gunna, Birkelund Svend, Andersen Vibeke, Stensballe Allan
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
AH Diagnostics, Aarhus, Denmark.
Data Brief. 2017 Oct 6;15:511-516. doi: 10.1016/j.dib.2017.09.059. eCollection 2017 Dec.
The datasets presented in this article are related to the research articles entitled "Neutrophil Extracellular Traps in Ulcerative Colitis: A Proteome Analysis of Intestinal Biopsies" (Bennike et al., 2015 [1]), and "Proteome Analysis of Rheumatoid Arthritis Gut Mucosa" (Bennike et al., 2017 [2]). The colon mucosa represents the main interacting surface of the gut microbiota and the immune system. Studies have found an altered composition of the gut microbiota in rheumatoid arthritis patients (Zhang et al., 2015; Vaahtovuo et al., 2008; Hazenberg et al., 1992) [5], [6], [7] and inflammatory bowel disease patients (Morgan et al., 2012; Abraham and Medzhitov, 2011; Bennike, 2014) [8], [9], [10]. Therefore, we characterized the proteome of colon mucosa biopsies from 10 inflammatory bowel disease ulcerative colitis (UC) patients, 11 gastrointestinal healthy rheumatoid arthritis (RA) patients, and 10 controls. We conducted the sample preparation and liquid chromatography mass spectrometry (LC-MS/MS) analysis of all samples in one batch, enabling label-free comparison between all biopsies. The datasets are made publicly available to enable critical or extended analyses. The proteomics data and search results, have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifiers PXD001608 for ulcerative colitis and control samples, and PXD003082 for rheumatoid arthritis samples.
《溃疡性结肠炎中的中性粒细胞胞外陷阱：肠道活检的蛋白质组分析》（本尼克等人，2015年[1]）以及《类风湿性关节炎肠道黏膜的蛋白质组分析》（本尼克等人，2017年[2]）。结肠黏膜是肠道微生物群与免疫系统的主要相互作用表面。研究发现，类风湿性关节炎患者（张等人，2015年；瓦赫托沃等人，2008年；哈曾贝格等人，1992年）[5]、[6]、[7]以及炎症性肠病患者（摩根等人，2012年；亚伯拉罕和梅德日托夫，2011年；本尼克，2014年）[8]、[9]、[10]的肠道微生物群组成发生了改变。因此，我们对10例炎症性肠病溃疡性结肠炎（UC）患者、11例胃肠道健康的类风湿性关节炎（RA）患者以及10例对照的结肠黏膜活检样本进行了蛋白质组特征分析。我们对所有样本进行了一批次的样品制备和液相色谱-质谱联用（LC-MS/MS）分析，从而能够对所有活检样本进行无标记比较。这些数据集已公开提供，以便进行批判性分析或扩展分析。蛋白质组学数据和搜索结果已通过PRIDE合作伙伴存储库存入蛋白质组交换联盟，溃疡性结肠炎和对照样本的数据集标识符为PXD001608，类风湿性关节炎样本的数据集标识符为PXD003082。
