先进甲状腺癌的分子影像：碘放射性示踪剂及其他。
Molecular imaging of advanced thyroid cancer: iodinated radiotracers and beyond.
机构信息
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, 1830 E. Monument St./Ste. 333, Baltimore, MD, 21287, USA.
Section of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
出版信息
Med Oncol. 2017 Oct 30;34(12):189. doi: 10.1007/s12032-017-1051-x.
An important aspect of differentiated thyroid cancer (DTC) management is disease localization by imaging. Functional imaging of thyroid cancer with iodinated radiotracers has been employed for metastatic disease detection for long. More recently, 2-deoxy-2-[18F] fluoro-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT), a non-iodinated ubiquitous PET tracer, has been used to detect non-radioiodine (RAI) avid disease. Advances in molecular imaging have led to the development of newer tracers like 18F-TFB (18F-tetrafluoroborate) that are transported through the sodium-iodide symporter (NIS) as well as 68 Ga-DOTATATE that image the somatostatin receptors sub-type 2 expressed in medullary thyroid cancer and some DTC. In coming years, there will be focus on newer receptor targets like prostate-specific membrane antigen expression and endoradiotherapies and theranostics.
分化型甲状腺癌（DTC）管理的一个重要方面是通过影像学进行疾病定位。用碘放射性示踪剂进行甲状腺癌的功能成像，长期以来一直用于检测转移性疾病。最近，2-脱氧-2-[18F]氟-D-葡萄糖（18F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT），一种非碘标记的普遍 PET 示踪剂，已被用于检测非放射性碘（RAI）不亲和性疾病。分子成像的进步导致了新型示踪剂的发展，如 18F-TFB（18F-四氟硼酸），它通过钠-碘转运体（NIS）转运，以及 68Ga-DOTATATE，它可以对表达在甲状腺髓样癌和一些 DTC 中的生长抑素受体亚型 2 进行成像。在未来几年，将专注于新型受体靶点，如前列腺特异性膜抗原表达和内放射治疗和治疗诊断。
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