Al Samad A, De Winter J, Gerbaux P, Jérôme C, Debuigne A
Center for Education and Research on Macromolecules (CERM), Research Unit "Complex and Entangled Systems: from Atoms to Materials" (CESAM), University of Liege (ULg), Sart-Tilman, Quartier Agora, Allée du Six Août, 11 Bldg B6a, B-4000 Liège, Belgium.
Chem Commun (Camb). 2017 Nov 9;53(90):12240-12243. doi: 10.1039/c7cc06463b.
Herein, we developed a straightforward aqueous synthesis of unprecedented alternating peptide-peptoid copolymers via a Ugi four-component reaction applied to dipeptides. Functional peptide-peptoid copolymers as well as block copolymers were produced in a single step in the presence of acrylic acid and carboxylic acid-terminated poly(ethylene glycol). The thermoresponsiveness of these polymers is highlighted.
