Department of Fundamental Energy Science, Graduate School of Energy Science, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-8501, Japan.
National Institute of Technology, Kagawa College, 355, Chokushi-cho, Takamatsu, Kagawa, 761-8058, Japan.
J Biomed Mater Res B Appl Biomater. 2018 Aug;106(6):2254-2265. doi: 10.1002/jbm.b.34025. Epub 2017 Oct 31.
We aimed to develop an effective process to provide bioactivity to carbon fiber-reinforced polyetheretherketone (PEEK), glass fiber-reinforced PEEK and glass fiber-reinforced poly(m-xylyleneadipamide)-6 (MXD6), possessing similar elastic modulus to cortical bone in this study. First, we formed fine pores on the surface of each substrate by a short-time sulfuric acid treatment. Second, in order to provide hydrophilic property, we treated the surfaces of each substrate with oxygen plasma. Finally, we deposited fine particles of amorphous calcium phosphate (PrAp) in the pores by soaking each substrate in SBF adjusted at pH 8.40, 25.0°C, and subsequently kept at 70.0°C for 24 h. By this treatment, we obtained the bioactive fiber-reinforced polymers. By soaking thus-obtained each material in SBF, apatite formation was induced on the whole surface of each substrate within 1 day by PrAp deposited in the pores and high apatite-forming ability was performed on each material. The adhesive strength between the apatite layer showed high value by mechanical anchoring effect generated by the apatite formed in the pores. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2254-2265, 2018.
本研究旨在开发一种有效工艺，以期赋予碳纤维增强聚醚醚酮（PEEK）、玻璃纤维增强 PEEK 和玻璃纤维增强聚间苯二甲酰间苯二胺-6（MXD6）生物活性，这些材料的弹性模量与皮质骨相似。首先，我们通过短时间的硫酸处理在各基底表面形成细微孔。其次，为了赋予亲水性，我们用氧等离子体处理各基底表面。最后，我们将各基底浸泡在 pH 值为 8.40、25.0°C 的 SBF 中，随后在 70.0°C 下保持 24 h，使无定形磷酸钙（PrAp）细颗粒沉积在孔中。通过这种处理，我们得到了具有生物活性的纤维增强聚合物。通过将如此获得的各材料浸泡在 SBF 中，在孔中沉积的 PrAp 可在 1 天内在各基底表面的整个表面上诱导形成磷灰石，并且各材料均具有较高的磷灰石形成能力。通过在孔中形成的磷灰石产生的机械锚固效应，磷灰石层的粘结强度表现出高值。©2017 年 Wiley 期刊出版公司。J 生物医学材料研究杂志 B：应用生物材料，106B：2254-2265，2018 年。
