Kim Hun, Lee Yang Ho, Kim Nam Kwon, Kang Inn Kyu
Institute of Jeil Life Engineering, Jeil Medical Corporation, Seoul 08375, Korea.
Department of Polymer Science and Engineering, Kyungpook National University, Daegu 41566, Korea.
Polymers (Basel). 2022 Apr 19;14(9):1633. doi: 10.3390/polym14091633.
Polyetheretherketone (PEEK) is the only polymer material that can replace titanium implants in the field of orthopedics. This is because the mechanical properties of PEEK are similar to those of bone, and PEEK has natural radiolucency, chemical stability, and sterilization resistance. Despite these advantages, PEEK has a disadvantage-that it is bio-inert. Therefore, many studies have attempted to change the bio-inertness of PEEK into bioactivity. Among them, a method of forming pores by acid treatment is attracting attention. In this study, an attempt was made to form pores on the surface of PEEK implant using a mixed acid of sulfuric acid and nitric acid. As a result, it was found that the condition when the PEEK surface is in contact with the acid is very important. That is, it was possible to form single-layered nanopores on the surface by contacting PEEK with a mixed acid under ultrasound. Additionally, by immobilizing type I collagen on the porous PEEK surface through dopamine coating, it was possible to obtain collagen-immobilized porous PEEK (P-PEEK-Col) with high compatibility with osteoblasts. This P-PEEK-Col has high potential for use as a bone substitute that promotes bone formation.
聚醚醚酮（PEEK）是骨科领域唯一可替代钛植入物的高分子材料。这是因为PEEK的机械性能与骨骼相似，且具有天然的射线可透过性、化学稳定性和抗杀菌性。尽管有这些优点，但PEEK有一个缺点——它具有生物惰性。因此，许多研究试图将PEEK的生物惰性转变为生物活性。其中，通过酸处理形成孔隙的方法备受关注。在本研究中，尝试使用硫酸和硝酸的混合酸在PEEK植入物表面形成孔隙。结果发现，PEEK表面与酸接触的条件非常重要。也就是说，通过在超声作用下使PEEK与混合酸接触，有可能在其表面形成单层纳米孔。此外，通过多巴胺涂层将I型胶原固定在多孔PEEK表面，有可能获得与成骨细胞具有高相容性的胶原固定化多孔PEEK（P-PEEK-Col）。这种P-PEEK-Col作为促进骨形成的骨替代物具有很高的应用潜力。
