Department of Cardiovascular Medicine, Duke University Medical Center, 2301 Erwin Rd, Durham, NC 27710. E-mail:
Am J Manag Care. 2017 Aug;23(8):474-480.
Pulmonary hypertension portends a poorer prognosis for blacks versus white populations, but the underlying reasons are poorly understood. We investigated associations of disease characteristics, insurance status, and race with clinical outcomes.
Retrospective cohort study of patients presenting for initial pulmonary hypertension evaluation at 2 academic referral centers.
We recorded insurance status (Medicare, Medicaid, private, self-pay), echocardiographic, and hemodynamics data from 261 patients (79% whites, 17% blacks) with a new diagnosis of pulmonary hypertension. Subjects were followed for 2.3 years for survival. Adjustment for covariates was performed with Cox proportional hazards modeling.
Compared with white patients, blacks were younger (50 ± 15 vs 53 ± 12 years; P = .04), with females representing a majority of patients in both groups (80% vs 66%; P = .08) and similar functional class distribution (class 2/3/4: 30%/52%/16% blacks vs 33%/48%/14% whites; P = .69). Blacks diagnosed with incident pulmonary hypertension were more frequently covered by Medicaid (12.5% vs 0.7%) and had less private insurance (50% vs 61%; P = .007) than whites. At presentation, blacks had more right ventricular dysfunction (P = .04), but similar mean pulmonary arterial pressure (46 vs 45 mm Hg, respectively; P = .66). After adjusting for age and functional class, blacks had greater mortality risk (hazard ratio [HR], 2.06; 95% confidence interval [CI], 1.18-3.44), which did not differ by race after additional adjustment for insurance status (HR, 1.74; 95% CI, 0.84-3.32; P =.13).
In a large cohort of patients with incident pulmonary hypertension, black patients had poorer right-side heart function and survival rates than white patients. However, adjustment for insurance status in our cohort removed differences in survival by race.
与白种人群相比,肺动脉高压预示着黑种人群的预后更差,但潜在原因仍不清楚。我们研究了疾病特征、保险状况和种族与临床结局的关系。
对 2 所学术转诊中心就诊的 261 例新发肺动脉高压患者进行回顾性队列研究。
我们记录了医疗保险、医疗补助、私人保险、自费保险的保险状况、超声心动图和血液动力学数据,这些患者被诊断为肺动脉高压。对 261 名患者(79%为白人,17%为黑人)进行了 2.3 年的生存随访。使用 Cox 比例风险模型进行协变量调整。
与白人患者相比,黑人患者更年轻(50 ± 15 岁比 53 ± 12 岁;P =.04),两组中女性均占多数(80%比 66%;P =.08),功能分级分布相似(2/3/4 级:黑人 30%/52%/16%,白人 33%/48%/14%;P =.69)。诊断为新发肺动脉高压的黑人患者中,有更多的人参加了医疗补助(12.5%比 0.7%),私人保险较少(50%比 61%;P =.007)。黑人患者就诊时右心室功能障碍更常见(P =.04),但平均肺动脉压相似(分别为 46 和 45 mmHg;P =.66)。在调整年龄和功能分级后,黑人患者的死亡率风险更高(风险比 [HR],2.06;95%置信区间 [CI],1.18-3.44),但在进一步按保险状况调整后,种族间的死亡率差异无统计学意义(HR,1.74;95%CI,0.84-3.32;P =.13)。
在一个大型的肺动脉高压新发病例队列中,黑人患者的右心功能和生存率均低于白人患者。然而,在我们的队列中,按保险状况调整后,种族间的生存率差异消失。