Emory University School of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Atlanta, GA; Atlanta VA Medical Center, Decatur, GA.
Emory University School of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Atlanta, GA; Atlanta VA Medical Center, Decatur, GA.
Ann Epidemiol. 2022 Nov;75:47-52. doi: 10.1016/j.annepidem.2022.09.001. Epub 2022 Sep 9.
Pulmonary hypertension (PH) is a heterogenous, often progressive disorder leading to right heart failure and death. Previous analyses show stable PH mortality rates from 1980 to 2001 but increasing from 2001 to 2010 especially among women and non-Hispanic (NH) Black. This study seeks to identify recent trends in PH mortality in the United States from 1999 to 2019.
Mortality rates among individuals more than or equal to 15 years of age were obtained from the Centers for Disease Control and Prevention's (CDC) Wide-Ranging Online Data for Epidemiology Research (WONDER) database. ICD-10 codes were used to identify individuals with PH.
Between 1999 and 2019, PH was included as a cause on 429,105 recorded deaths. The average age-adjusted PH mortality rate was 7.9 per 100,000 individuals and increased by 1.9% per year. Higher age-adjusted mortality rates were experienced by females and NH Black persons. The crude mortality rate was 105.4 per 100,000 among those decedents 85 or older. From 1999 to 2019, mortality in PH and left heart disease co-occurrence increased at nearly double the annual rate of the overall PH group.
Despite therapeutic advances for selected PH subgroups, the overall age-adjusted PH mortality rate increased significantly from 1999 to 2019 and previously reported racial disparities have persisted. These findings emphasize the need for additional study to improve outcomes in PH.
肺动脉高压（PH）是一种异质性的、常进展性疾病，可导致右心衰竭和死亡。先前的分析显示，1980 年至 2001 年 PH 的死亡率稳定，但自 2001 年至 2010 年，尤其是在女性和非西班牙裔（NH）黑人中，死亡率呈上升趋势。本研究旨在确定美国 1999 年至 2019 年期间 PH 死亡率的近期趋势。
从疾病控制和预防中心（CDC）的广域在线流行病学研究（WONDER）数据库中获取 15 岁及以上人群的死亡率数据。使用国际疾病分类第 10 版（ICD-10）代码来识别 PH 患者。
在 1999 年至 2019 年间，PH 被列为 429105 例记录死亡的原因之一。平均年龄调整后的 PH 死亡率为每 10 万人中有 7.9 人，每年增长 1.9%。女性和 NH 黑人的年龄调整后死亡率较高。85 岁及以上死者的粗死亡率为每 10 万人 105.4 人。从 1999 年至 2019 年，PH 与左心疾病同时发生的死亡率以接近 PH 总人群的两倍的年增长率增长。
尽管针对某些 PH 亚组的治疗有所进展，但从 1999 年至 2019 年，整体年龄调整后的 PH 死亡率显著上升，先前报告的种族差异仍持续存在。这些发现强调了需要进一步研究以改善 PH 的预后。
