质子泵抑制剂治疗嗜酸性食管炎：一种范式转变。 - Suppr

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Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis: A Paradigm Shift.

作者信息

Molina-Infante Javier, Lucendo Alfredo J

机构信息

Department of Gastroenterology, Hospital Universitario San Pedro de Alcantara, Caceres, Spain.

Centro de Investigacion Biomedica en Red Enfermedades Hepaticas y Digestivas (CIBEREHD), Madrid, Spain.

出版信息

Am J Gastroenterol. 2017 Dec;112(12):1770-1773. doi: 10.1038/ajg.2017.404. Epub 2017 Oct 31.

DOI:10.1038/ajg.2017.404

PMID:29087399

Abstract

摘要

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本文引用的文献

Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults.嗜酸性食管炎指南：儿童和成人诊断与管理的循证声明及建议

United European Gastroenterol J. 2017 Apr;5(3):335-358. doi: 10.1177/2050640616689525. Epub 2017 Jan 23.

Eosinophilic esophagitis versus proton pump inhibitor-responsive esophageal eosinophilia: Transcriptome analysis.嗜酸性粒细胞性食管炎与质子泵抑制剂反应性食管嗜酸性粒细胞增多症：转录组分析

J Allergy Clin Immunol. 2017 Jun;139(6):2010-2013.e4. doi: 10.1016/j.jaci.2016.11.028. Epub 2017 Jan 4.

Sustained Acid Suppression by Potassium-Competitive Acid Blocker (P-CAB) May Be An Attractive Treatment Candidate for Patients with Eosinophilic Esophagitis.钾离子竞争性酸阻滞剂（P-CAB）持续抑制胃酸可能是嗜酸性食管炎患者颇具吸引力的治疗选择。

Am J Gastroenterol. 2016 Aug;111(8):1203-4. doi: 10.1038/ajg.2016.167.

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Dual response to dietary/topical steroid and proton pump inhibitor therapy in adult patients with eosinophilic esophagitis.成年嗜酸性粒细胞性食管炎患者对饮食/局部类固醇和质子泵抑制剂治疗的双重反应

J Allergy Clin Immunol. 2016 Mar;137(3):931-4.e2. doi: 10.1016/j.jaci.2015.07.033. Epub 2015 Sep 12.

Proton pump inhibitor-responsive esophageal eosinophilia does not preclude food-responsive eosinophilic esophagitis.质子泵抑制剂反应性食管嗜酸性粒细胞增多症并不排除食物反应性嗜酸性粒细胞性食管炎。

J Allergy Clin Immunol. 2016 Feb;137(2):631-3. doi: 10.1016/j.jaci.2015.07.008. Epub 2015 Aug 25.

Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.质子泵抑制剂反应性食管嗜酸性粒细胞增多症的转录组分析揭示了质子泵抑制剂可逆转的过敏性炎症。

J Allergy Clin Immunol. 2015 Jan;135(1):187-97. doi: 10.1016/j.jaci.2014.08.043. Epub 2014 Oct 19.

Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression.质子泵抑制剂反应性食管嗜酸性粒细胞增多与嗜酸性粒细胞趋化因子-3的下调及Th2细胞因子的过表达相关。

Aliment Pharmacol Ther. 2014 Oct;40(8):955-65. doi: 10.1111/apt.12914. Epub 2014 Aug 11.

Proton pump inhibitors partially restore mucosal integrity in patients with proton pump inhibitor-responsive esophageal eosinophilia but not eosinophilic esophagitis.质子泵抑制剂可部分恢复质子泵抑制剂反应性食管嗜酸性粒细胞增多症患者的黏膜完整性，但不能恢复嗜酸性粒细胞性食管炎。

Clin Gastroenterol Hepatol. 2014 Nov;12(11):1815-23.e2. doi: 10.1016/j.cgh.2014.02.037. Epub 2014 Mar 19.

Molecular diagnosis of eosinophilic esophagitis by gene expression profiling.通过基因表达谱分析进行嗜酸性粒细胞性食管炎的分子诊断。

Gastroenterology. 2013 Dec;145(6):1289-99. doi: 10.1053/j.gastro.2013.08.046. Epub 2013 Aug 23.

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