Institute of Bioinformatics, University Medical Center Göttingen, Georg August University, D-37077 Göttingen, Germany.
geneXplain GmbH, D-38302 Wolfenbüttel, Germany.
Nucleic Acids Res. 2018 Jan 4;46(D1):D343-D347. doi: 10.1093/nar/gkx987.
TFClass is a resource that classifies eukaryotic transcription factors (TFs) according to their DNA-binding domains (DBDs), available online at http://tfclass.bioinf.med.uni-goettingen.de. The classification scheme of TFClass was originally derived for human TFs and is expanded here to the whole taxonomic class of mammalia. Combining information from different resources, checking manually the retrieved mammalian TFs sequences and applying extensive phylogenetic analyses, >39 000 TFs from up to 41 mammalian species were assigned to the Superclasses, Classes, Families and Subfamilies of TFClass. As a result, TFClass now provides the corresponding sequence collection in FASTA format, sequence logos and phylogenetic trees at different classification levels, predicted TF binding sites for human, mouse, dog and cow genomes as well as links to several external databases. In particular, all those TFs that are also documented in the TRANSFAC® database (FACTOR table) have been linked and can be freely accessed. TRANSFAC® FACTOR can also be queried through an own search interface.
TFClass 是一个在线资源，根据 DNA 结合域 (DBD) 将真核转录因子 (TFs) 分类，网址为 http://tfclass.bioinf.med.uni-goettingen.de。TFClass 的分类方案最初是为人类 TFs 设计的，现在扩展到了哺乳动物的整个分类。通过整合来自不同资源的信息，手动检查检索到的哺乳动物 TFs 序列，并进行广泛的系统发育分析，我们将超过 39000 个来自 41 种哺乳动物的 TFs 分配到了 TFClass 的超类、类、家族和亚家族中。因此，TFClass 现在提供了 FASTA 格式的相应序列集、序列标志和不同分类水平的系统发育树，以及针对人类、小鼠、狗和牛基因组的预测 TF 结合位点，以及与几个外部数据库的链接。特别是，所有在 TRANSFAC® 数据库（FACTOR 表）中也有记录的 TFs 都已被链接，可以免费访问。TRANSFAC® FACTOR 也可以通过自己的搜索界面进行查询。
