Robbins T W, Granon S, Muir J L, Durantou F, Harrison A, Everitt B J
Department of Experimental Psychology, University of Cambridge, Cambridge, UK.
Ann N Y Acad Sci. 1998 Jun;846(1):222-237. doi: 10.1111/j.1749-6632.1998.tb09740.x.
The monoaminergic and cholinergic systems are implicated in different forms of behavioral arousal that can be dissected in terms of their forebrain targets and the nature of the behavioral processes they modulate in distinct regions. Thus, evidence in rats with selective neurochemical manipulations tested behaviorally using an analog of an attentional task developed for human subjects indicates that the coeruleo-cortical noradrenergic system is implicated in divided and selective attention, the basal forebrain cholinergic system in stimulus detection, the mesostriatal and mesolimbic dopaminergic systems in response speed and vigor, and the mesencephalic serotoninergic or 5-HT systems in response inhibition. Our recent studies have focused on fractionating, in the same task, the differential contributions of the dorsal and median raphé 5-HT systems as well as elucidating the functions of the mesocortical dopaminergic system, each of which may be relevant to understanding the behavioral and cognitive sequelae of cocaine administration in human subjects as well as in experimental animals.
单胺能和胆碱能系统与不同形式的行为唤醒有关，这些行为唤醒可以根据它们在前脑的靶点以及它们在不同区域调节的行为过程的性质来剖析。因此，对使用为人类受试者开发的注意力任务类似物进行行为测试的选择性神经化学操纵大鼠的研究表明，蓝斑 - 皮质去甲肾上腺素能系统与分散性和选择性注意力有关，基底前脑胆碱能系统与刺激检测有关，中脑纹状体和中脑边缘多巴胺能系统与反应速度和活力有关，而中脑血清素能或5 - HT系统与反应抑制有关。我们最近的研究集中在同一任务中区分背侧和中缝5 - HT系统的不同贡献，以及阐明中脑皮质多巴胺能系统的功能，这两者都可能与理解人类受试者以及实验动物中可卡因给药后的行为和认知后遗症有关。
