Famitafreshi Hamidreza, Karimian Morteza
Physiology Department, Tehran University of Medical Sciences-International Campus, Tehran, Iran.
Physiology Department, Tehran University of Medical Sciences, Tehran, Iran.
Biomedicine (Taipei). 2021 Jun 1;11(2):5-10. doi: 10.37796/2211-8039.1120. eCollection 2021.
Drug addiction is a dangerous condition that is the concern of human societies. Nevertheless, several issues exist ahead of people with a drug use disorder during addiction. Accordingly, various types of studies have been conducted to understand better the problems that people with a drug use disorder encountered. People with a drug use disorder usually have a problem tolerating the withdrawal period and some relapse to drug abuse. Complementary studies further revealed that some hormones like oxytocin (OXT), vasopressin, hypothalamic-pituitary-adrenal axis (HPA) axis hormones, sex hormones, thyroid hormones, and nutritional hormones are probably involved in addiction processes. These hormones completely with different mechanisms can influence drug users' ultimate outcome. As we will see, these hormones influence tolerance, sensitization, and compulsive drug seeking and taking behavior. In this review, they have been further discussed.
药物成瘾是一种危险状况，受到人类社会的关注。然而，在成瘾过程中，患有药物使用障碍的人面临着几个问题。因此，已经进行了各种类型的研究，以更好地了解患有药物使用障碍的人所遇到的问题。患有药物使用障碍的人通常难以耐受戒断期，并且有些人会复吸药物滥用。补充研究进一步表明，一些激素，如催产素（OXT）、血管加压素、下丘脑-垂体-肾上腺轴（HPA轴）激素、性激素、甲状腺激素和营养激素，可能参与成瘾过程。这些激素通过完全不同的机制可以影响吸毒者的最终结局。正如我们将看到的，这些激素会影响耐受性、敏化以及强迫性觅药和用药行为。在本综述中，对它们进行了进一步讨论。
