Alabi Quadri Kunle, Olukiran Olaoluwa Sesan, Adefisayo Modinat Adebukola, Fadeyi Benson Akinloye
a Department of Physiological Sciences, Faculty of Basic Medical Sciences , Obafemi Awolowo University , Ile-Ife , Osun State , Nigeria.
b Department of Physiology, Faculty of Basic Medical Sciences , University of Medical Sciences , Ondo State , Nigeria.
J Diet Suppl. 2018 Sep 3;15(5):649-664. doi: 10.1080/19390211.2017.1380105. Epub 2017 Oct 31.
Nauclea latifolia is used in traditional medicine for the treatment of male reproductive diseases. Despite its vast uses, its effects on the male reproductive system have not been scientifically proven. This study aimed to investigate the effects of Nauclea latifolia root decoction on sexual behavior and functions in male rabbits. Twenty-four male rabbits were divided into four groups: The first group received daily distilled water orally. The second, third, and fourth groups were orally treated with 100, 200, and 400 mg/kg body weight of Nuclea latifolia root, respectively. Sexual behavior parameters were carried out on weeks 1, 2, and 3 of the study. Testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured from the serum, while the testes tissue samples were used for antioxidant and histopathological examinations. Treatment with 200 and 400 mg/kg body weight resulted in significantly (p < .05) increased frequencies of mounting and intromission. In addition, the ejaculation latency was significantly prolonged (p < .05). The latencies of mounting and intromission were significantly decreased (p < .05), whereas ejaculation frequency increased. Serum testosterone, FSH, and LH increased significantly (p < .05) after treatment with Nuclea latifolia. There was an increase in epididymal sperm counts at 200 and 400 mg/kg body weight doses compared to the control. The extract also increased sperm motility and viability and improved testicular oxidative status. Histological examination revealed an increase in germinal layer thickness. The present study suggests that treatment with N. latifolia improves male sexual function and fertility and protects the testes from oxidative damage.
阔叶乌檀在传统医学中用于治疗男性生殖系统疾病。尽管其用途广泛，但其对男性生殖系统的影响尚未得到科学证实。本研究旨在探讨阔叶乌檀根煎剂对雄性家兔性行为和生殖功能的影响。将24只雄性家兔分为四组：第一组每日口服蒸馏水。第二、第三和第四组分别口服100、200和400毫克/千克体重的阔叶乌檀根。在研究的第1、2和3周进行性行为参数测定。从血清中检测睾酮、促卵泡激素（FSH）和促黄体生成素（LH），同时将睾丸组织样本用于抗氧化和组织病理学检查。200和400毫克/千克体重剂量的处理导致爬跨和插入频率显著增加（p < 0.05）。此外，射精潜伏期显著延长（p < 0.05）。爬跨和插入潜伏期显著缩短（p < 0.05），而射精频率增加。阔叶乌檀处理后，血清睾酮、FSH和LH显著增加（p < 0.05）。与对照组相比，200和400毫克/千克体重剂量的附睾精子数量增加。提取物还提高了精子活力和存活率，并改善了睾丸氧化状态。组织学检查显示生发层厚度增加。本研究表明，阔叶乌檀处理可改善男性性功能和生育能力，并保护睾丸免受氧化损伤。
